Time trends of overall survival among metastatic breast cancer patients in the real-life ESME cohort

转移性乳腺癌 队列 医学 肿瘤科 乳腺癌 内科学 总体生存率 癌症 队列研究
作者
E. Gobbini,Monia Ezzalfani,Véronique Dièras,Thomas Bachelot,Étienne Brain,Marc Debled,William Jacot,Marie‐Ange Mouret‐Reynier,Anthony Gonçalvès,Florence Dalenc,Anne Patsouris,Jean Marc Ferrero,Christelle Lévy,Véronique Lorgis,Laurence Vanlemmens,Claudia Lefeuvre‐Plesse,Simone Mathoulin‐Pélissier,Thierry Petit,Lionel Uwer,Christelle Jouannaud,Marianne Leheurteur,Magali Lacroix‐Triki,Audrey Lardy Cleaud,Mathieu Robain,Coralie Courtinard,Christian Cailliot,David Pérol,Suzette Delaloge
出处
期刊:European Journal of Cancer [Elsevier BV]
卷期号:96: 17-24 被引量:249
标识
DOI:10.1016/j.ejca.2018.03.015
摘要

Aim Real-life analysis of overall survival (OS) trends among metastatic breast cancer (MBC) patients may help define medical needs and evaluate the impact of public health investments. The present study aimed to evaluate the independent impact of the year of MBC diagnosis on OS in the Epidemio-Strategy-Medical-Economical (ESME)-MBC cohort. Methods ESME-MBC (NCT03275311) is a French, national, multicentre, observational cohort including 16,702 consecutive newly diagnosed MBC patients (01 January 2008–31 December 2014). Of 16,680 eligible patients, 15,085 had full immunohistochemistry data, allowing classification as hormone receptor–positive and HER2-negative (HR+/HER2–, N = 9907), HER2-positive (HER2+, N = 2861) or triple-negative (HR–/HER2–, N = 2317) subcohorts. Multivariate analyses of OS were conducted among the full ESME cohort and subcohorts. Results Median OS of the whole cohort was 37.22 months (95% confidence interval [CI], 36.3–38.04). Year of diagnosis was an independent predictor of OS (hazard ratio 0.98 [95% CI, 0.97–1.00], P = .01) together with age, subtype, disease-free interval, visceral metastases and number of organs involved. Median OS of HR+/HER2–, HER2+ and HR–/HER2– subcohorts was, respectively, 42.12 (95% CI, 40.90–43.10), 44.91 (95% CI, 42.51–47.90) and 14.52 (95% CI, 13.70–15.24) months. Year of diagnosis was a strong independent predictor of OS in HER2+ subcohort (hazard ratio 0.91 [95% CI, 0.88–0.94], P < .001), but not in HR+/HER2– nor HR–/HER2– subcohorts (hazard ratio 1.00 [95% CI, 0.98–1.01], P = .80 and 1.00 [95% CI, 0.97–1.02], P = .90, respectively). Conclusions The OS of MBC patients has slightly improved over the past decade. However, this effect is confined to HER2+ cases, highlighting the need of new strategies in the other subtypes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
失眠的霸完成签到,获得积分10
1秒前
ChatGPT发布了新的文献求助10
2秒前
4秒前
多发论文完成签到,获得积分20
5秒前
5秒前
6秒前
su发布了新的文献求助10
6秒前
Xw关闭了Xw文献求助
6秒前
大个应助fjm采纳,获得10
9秒前
而为发布了新的文献求助30
9秒前
机智思真发布了新的文献求助10
9秒前
木樨316完成签到,获得积分10
9秒前
12秒前
花花完成签到 ,获得积分10
14秒前
沉默的小天鹅应助耀阳采纳,获得10
14秒前
lilila666完成签到,获得积分10
14秒前
16秒前
17秒前
17秒前
lilila666发布了新的文献求助10
19秒前
艺术家脾气完成签到,获得积分10
19秒前
丘比特应助qqq采纳,获得10
21秒前
23秒前
crazy发布了新的文献求助10
24秒前
Wayne72完成签到,获得积分0
29秒前
阿飞发布了新的文献求助10
29秒前
Zoki完成签到,获得积分10
30秒前
mini发布了新的文献求助10
31秒前
32秒前
烟雨完成签到,获得积分10
34秒前
彭栋应助文献采纳,获得30
34秒前
祖国小红花完成签到,获得积分20
34秒前
fighting完成签到 ,获得积分10
35秒前
来我家喝桂花茶完成签到,获得积分10
40秒前
40秒前
852应助一方通行采纳,获得10
40秒前
41秒前
41秒前
量子星尘发布了新的文献求助10
42秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173