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Role of the endogenous cannabinoid receptor 1 in brain injury induced by chronic intermittent hypoxia in rats

医学 大麻素 神经科学 内科学 大麻素受体 内大麻素系统 缺氧(环境) 心理学 药理学 内生 受体 麻醉 化学 敌手 氧气 有机化学
作者
Xiao-Ling Gao,Shu‐Jie Wu,Yanting Dong,Ya‐Qiong Huang,Yan Chen,Yan Qiao,Zhanjun Dou,Bei Wang
出处
期刊:International Journal of Neuroscience [Taylor & Francis]
卷期号:128 (9): 797-804 被引量:8
标识
DOI:10.1080/00207454.2017.1420069
摘要

This study investigated the effect of rimonabant, a cannabinoid receptor type 1 antagonist, on calcium/calmodulin- dependent protein kinase II and cannabinoid receptor type 1 in chronic intermittent hypoxia.Healthy male rats were divided into control group, intermittent hypoxia group for 4 or 6 weeks, hypoxic intervention group that received rimonabant (1 mg/kg/d) before exposure to hypoxia for 4 or 6 weeks (n = 10/group). Morphological changes and expressions of the two indexes in the cerebral hippocampus cells were determined by haematoxylin-eosin staining and immunohistochemistry, respectively.In the intermittent hypoxia group at 4 weeks, the hippocampal cells were damaged with sparse cytoplasm and unclear boundaries, which are even worse at 6 weeks. In contrast, the hippocampal cells of the hypoxic intervention group were neatly arranged at 4 weeks. At 6 weeks, cells were larger with scarce cytoplasm and nuclear changes indicative of cell death. Calcium/calmodulin-dependent protein kinase II and cannabinoid receptor type 1 expression in the cerebral hippocampus was elevated in the intermittent hypoxia group at 4 weeks with even greater at 6 weeks. Cannabinoid receptor type 1 expression was reduced in the hypoxic intervention group compared to the intermittent hypoxia group. Correlation analysis revealed significant positive correlation of them in the intermittent hypoxia group.Chronic intermittent hypoxia induced structural damage in the hippocampus and increased cannabinoid receptor type 1 and calcium/calmodulin-dependent protein kinase II expression, which may mediate cognitive impairment associated with chronic intermittent hypoxia. Rimonabant had a protective effect against chronic intermittent hypoxia.
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