Exposure to biological therapies during conception and pregnancy: a systematic review

医学 怀孕 优势比 银屑病 人口 混淆 置信区间 队列研究 梅德林 产科 内科学 免疫学 环境卫生 遗传学 政治学 法学 生物
作者
Elizabeth Pottinger,Richard Woolf,L.S. Exton,A. D. Burden,C Nelson‐Piercy,Catherine Smith
出处
期刊:British Journal of Dermatology [Oxford University Press]
卷期号:178 (1): 95-102 被引量:39
标识
DOI:10.1111/bjd.15802
摘要

Biological therapies are effective treatments for psoriasis and are often prescribed to women of child‐bearing age. To evaluate the safety of biological therapy in conception and/or pregnancy. We performed a systematic review of PubMed, MEDLINE, Embase and Cochrane databases for multivariate‐adjusted studies of women exposed to biologics relevant to the treatment of psoriasis during conception and/or pregnancy. We identified four population‐based cohort studies involving 1300 women exposed to tumour necrosis factor (TNF)‐α inhibitors (TNFi) 3 months prior to or during the first 3 months of pregnancy. These studies showed a trend towards drug‐specific harm with TNFi exposure in women with different inflammatory diseases, with an increased risk of congenital malformations [three studies; odds ratio (OR) range 1·32–1·64] and preterm birth (one study; OR 1·69, 95% confidence interval 1·10–2·60). This trend did not reach statistical significance in all studies; study heterogeneity, variation across comparator cohorts, inadequate adjustment for important confounding variables such as co‐therapy, and an absence of a common constellation of malformations means there is uncertainty about the causal role of TNFi. No studies specifically addressed the effect of TNFi exposure in psoriasis during conception and/or pregnancy, or of interleukin (IL)‐17 and IL‐12/23 antagonists in any indication. When counselling women these findings must be balanced against the potential impact of untreated severe psoriasis on conception and/or pregnancy and maternal wellbeing; ongoing pharmacovigilance via registries remains essential to address this evidence gap.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
852应助黄贰叁采纳,获得10
刚刚
FashionBoy应助lm采纳,获得10
2秒前
翻羽发布了新的文献求助10
2秒前
2秒前
2秒前
qiang发布了新的文献求助10
3秒前
ludov发布了新的文献求助30
3秒前
大翟完成签到,获得积分10
4秒前
墩墩应助ENG采纳,获得10
5秒前
贰鸟应助飞儿随缘采纳,获得20
5秒前
传统的斓完成签到,获得积分10
6秒前
烟花应助一一采纳,获得10
7秒前
赘婿应助MoriZhang采纳,获得10
7秒前
ao20000106发布了新的文献求助10
7秒前
朴实的河马完成签到,获得积分10
8秒前
8秒前
lll完成签到,获得积分10
9秒前
李健应助诚心的以寒采纳,获得10
9秒前
11秒前
12秒前
14秒前
集典完成签到 ,获得积分10
16秒前
共享精神应助MoriZhang采纳,获得10
17秒前
lm发布了新的文献求助10
17秒前
17秒前
泡棉胶发布了新的文献求助10
18秒前
Akim应助张利双采纳,获得10
19秒前
诚心的以寒完成签到,获得积分10
20秒前
20秒前
20秒前
痴情的小蕊完成签到,获得积分10
21秒前
bkagyin应助翻羽采纳,获得10
22秒前
22秒前
黄贰叁发布了新的文献求助10
23秒前
23秒前
24秒前
李li发布了新的文献求助10
25秒前
完美世界应助研友_841e4L采纳,获得10
25秒前
25秒前
普契尼发布了新的文献求助10
26秒前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3962822
求助须知:如何正确求助?哪些是违规求助? 3508736
关于积分的说明 11142697
捐赠科研通 3241520
什么是DOI,文献DOI怎么找? 1791604
邀请新用户注册赠送积分活动 872987
科研通“疑难数据库(出版商)”最低求助积分说明 803517