Abstract This study reports new temperature-dependent yield strength models for solid solution strengthening binary and multi-component alloys. The models take into account the contributions of base metal, solid solution strengthening, and grain boundary strengthening at different temperatures. Comparisons for different Nickel-based alloys are made between experimental and predicted data with all parameters obtaining from literatures and handbooks and they are in good agreement in a wide range of temperature. This study points out that the yield strength of solid solution strengthening alloys is very sensitive to the lattice misfit. It is not suitable to cursorily estimate the lattice misfit by the atomic radius of solute and solvent. In addition, the variation with temperature of the contribution of each mechanism to the yield strength of solid solution strengthening Nickel-based alloys is firstly made in this study. The study also provides some useful suggestions to improve the temperature-dependent yield strength of solid solution strengthening Nickel-based alloys in the manufacturing.