氨
谷氨酸脱氢酶
化学
生物化学
氨基酸
代谢组
氮气
细胞外
代谢途径
氮气循环
谷氨酸受体
新陈代谢
代谢物
有机化学
受体
作者
Jessica B. Spinelli,Haejin Yoon,Alison E. Ringel,Sarah Jeanfavre,Clary B. Clish,Marcia C. Haigis
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-11-17
卷期号:358 (6365): 941-946
被引量:305
标识
DOI:10.1126/science.aam9305
摘要
Cancer cells put ammonia back to work Ammonia, often considered a metabolic waste product, can be recycled to build new amino acids. Rapidly proliferating cells produce extracellular nitrogen. Spinelli et al. used metabolic tracing of 15 N to follow the fate of extracellular ammonia and its incorporation into more than 200 components of the nitrogen metabolome (see the Perspective by Dang). Accumulation of ammonia enabled glutamate dehydrogenase to function in reductive amination, which allowed incorporation of nitrogen from ammonia back into amino acids. Experiments in mice also showed incorporation of ammonia into glutamate, aspartate, and proline. Science , this issue p. 941 ; see also p. 862
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