减毒疫苗
黄热病疫苗
病毒学
接种疫苗
黄热病
医学
免疫学
生物安全
疾病
病毒
生物
毒力
内科学
生物化学
基因
病理
出处
期刊:Vaccine
[Elsevier]
日期:2017-03-31
卷期号:35 (44): 5951-5955
被引量:82
标识
DOI:10.1016/j.vaccine.2017.03.032
摘要
Yellow fever (YF) is regarded as the original hemorrhagic fever and has been a major public health problem for at least 250 years. A very effective live attenuated vaccine, strain 17D, was developed in the 1930s and this has proved critical in the control of the disease. There is little doubt that without the vaccine, YF virus would be considered a biosafety level 4 pathogen. Significantly, YF is currently the only disease where an international vaccination certificate is required under the International Health Regulations. Despite having a very successful vaccine, there are occasional issues of supply and demand, such as that which occurred in Angola and Democratic Republic of Congo in 2016 when there was insufficient vaccine available. For the first time fractional dosing of the vaccine was approved on an emergency basis. Thus, continued vigilance and improvements in supply and demand are needed in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI