Research progress of Sirtuins in DNA damage repair

细胞凋亡 [2] .DNA损伤的类型不同, 细胞所选择的修 复机制也不同, 如直接修复(direct repair, DR)、切除 修复(excision repair, ER)、错配修复(mismatch repair, MMR)、同源重组修复(homologous repair, HR)、非同 源末端连接(non-homologous end-joining, NHEJ)和跨损 伤DNA合成(translesion DNA synthesis, TLS)等 [3] .