Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis

Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis Engler et al. (10) demonstrated that SIRT1 modulates the activity of RA SFs.SIRT2 protein and mRNA levels are reported to be significantly decreased in joint tissues of mice with collagen-induced arthritis (CIA) (11).In contrast, SIRT6 protein levels are reported to be moderately increased in the same arthritis experimental model ( 12).The effect of SIRTs on epigenetics, intracellular pathways, and cytokines suggests that they play a role in the pathogenesis of RA (8,9).This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA and to determine their potential effects on the disease phenotype.