神经病理学
后代
精神分裂症(面向对象编程)
自闭症
自闭症谱系障碍
心理学
精神科
神经科学
医学
怀孕
生物
疾病
遗传学
病理
作者
Myka L. Estes,A. Kimberley McAllister
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-08-19
卷期号:353 (6301): 772-777
被引量:906
标识
DOI:10.1126/science.aag3194
摘要
Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum disorder and schizophrenia. Animal models corroborate this link and demonstrate that maternal immune activation (MIA) alone is sufficient to impart lifelong neuropathology and altered behaviors in offspring. This Review describes common principles revealed by these models, highlighting recent findings that strengthen their relevance for schizophrenia and autism and are starting to reveal the molecular mechanisms underlying the effects of MIA on offspring. The role of MIA as a primer for a much wider range of psychiatric and neurologic disorders is also discussed. Finally, the need for more research in this nascent field and the implications for identifying and developing new treatments for individuals at heightened risk for neuroimmune disorders are considered.
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