Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter

An organocatalytic asymmetric H–N 3 insertion of α-carbonyl sulfoxonium ylides has been developed, providing efficient access to α -azido ketones bearing labile tertiary stereocenters and complementing the metal carbene insertion chemistry.