Nonalcoholic fatty liver disease and diabetes

非酒精性脂肪肝 医学 脂肪肝 脂肪变性 胰岛素抵抗 内科学 糖尿病 代谢综合征 2型糖尿病 慢性肝病 胃肠病学 脂肪性肝炎 血脂异常 肝硬化 疾病 内分泌学
作者
Maria Irene Bellini,Irene Urciuoli,Giovanni Del Gaudio,Giorgia Polti,Gian Domenico Iannetti,Elena Gangitano,Eleonora Lori,Carla Lubrano,Vito Cantisani,Salvatore Sorrenti,Vito D’Andrea
出处
期刊:World Journal of Diabetes [Baishideng Publishing Group Co (World Journal of Diabetes)]
卷期号:13 (9): 668-682 被引量:4
标识
DOI:10.4239/wjd.v13.i9.668
摘要

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world and represents a clinical-histopathologic entity where the steatosis component may vary in degree and may or may not have fibrotic progression. The key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and efflux. Strong epidemiological, biochemical, and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance; thus the association between diabetes and NAFLD is widely recognized in the literature. Since NAFLD is the hepatic manifestation of a metabolic disease, it is also associated with a higher cardio-vascular risk. Conventional B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis, although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these patients. Treatment of NAFLD patients depends on the disease severity, ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic steatohepatitis. Abstinence from alcohol, a Mediterranean diet, and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events, as per all diabetic patients. In addition, weight loss induced by bariatric surgery seems to also be effective in improving liver features, together with the benefits for diabetes control or resolution, dyslipidemia, and hypertension. Finally, liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western countries. This review offers a comprehensive multidisciplinary approach to NAFLD, highlighting its connection with diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FengyaoWang完成签到,获得积分10
刚刚
开朗焦完成签到,获得积分10
刚刚
机械师简完成签到,获得积分20
1秒前
小巧的柚子完成签到,获得积分10
1秒前
xu55完成签到,获得积分10
1秒前
1秒前
自然的哈密瓜完成签到,获得积分10
1秒前
ania完成签到,获得积分10
2秒前
QIN完成签到,获得积分10
2秒前
姜大喵完成签到,获得积分10
2秒前
doc.level完成签到,获得积分10
3秒前
丰富的小甜瓜完成签到,获得积分10
3秒前
把石头还给石头完成签到,获得积分10
3秒前
zongzi12138完成签到,获得积分0
4秒前
独特乘云完成签到,获得积分10
4秒前
晶晶完成签到,获得积分10
4秒前
TOF完成签到,获得积分10
4秒前
kying完成签到 ,获得积分10
5秒前
5秒前
duoduo完成签到,获得积分10
6秒前
鲁涔完成签到,获得积分10
7秒前
zonker完成签到,获得积分10
7秒前
7秒前
聆听完成签到,获得积分10
7秒前
房LY完成签到,获得积分10
7秒前
六仔完成签到,获得积分10
7秒前
CHEM_XIE完成签到,获得积分10
8秒前
zhongyi完成签到,获得积分10
8秒前
mmm完成签到,获得积分10
8秒前
8秒前
研友_nVWP2Z完成签到 ,获得积分10
8秒前
海北完成签到 ,获得积分10
8秒前
9秒前
9秒前
xiuwen完成签到,获得积分10
9秒前
Debra完成签到,获得积分10
9秒前
Epiphany完成签到,获得积分10
10秒前
兵临城下发布了新的文献求助10
10秒前
清脆初晴发布了新的文献求助30
10秒前
爱吃菠萝蜜完成签到,获得积分10
10秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3244942
求助须知:如何正确求助?哪些是违规求助? 2888587
关于积分的说明 8253996
捐赠科研通 2557043
什么是DOI,文献DOI怎么找? 1385639
科研通“疑难数据库(出版商)”最低求助积分说明 650203
邀请新用户注册赠送积分活动 626369