免疫系统
细胞毒性T细胞
生物
CD8型
癌症研究
髓系细胞
化学
髓样
细胞生物学
免疫学
生物化学
体外
作者
Hongyun Zhao,Da Teng,Jing Wang,Xincheng Xu,Jiajia Chen,Teng‐Jia Jiang,Austin Y. Feng,Shouxin Zhang,Dennie T. Frederick,Lei Gu,Li Cai,John M. Asara,Marina Pasca di Magliano,Genevieve M. Boland,Keith T. Flaherty,Kenneth D. Swanson,David Liu,Joshua D. Rabinowitz,Bin Zheng
标识
DOI：10.1038/s42255-022-00676-9
摘要
The tumour microenvironment possesses mechanisms that suppress anti-tumour immunity. Itaconate is a metabolite produced from the Krebs cycle intermediate cis-aconitate by the activity of immune-responsive gene 1 (IRG1). While it is known to be immune modulatory, the role of itaconate in anti-tumour immunity is unclear. Here, we demonstrate that myeloid-derived suppressor cells (MDSCs) secrete itaconate that can be taken up by CD8
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