Protective Effect of Nicorandil on Contrast-Induced Acute Kidney Injury After Emergency Percutaneous Coronary Intervention

医学 尼可地尔 传统PCI 经皮冠状动脉介入治疗 内科学 肾功能 急性肾损伤 肌酐 心肌梗塞 造影剂肾病 心脏病学 肌酸激酶
作者
Zuozhong Yu,Zheng-xiong Xu,Yuehua Ruan,Longlong Hu,Minghua Wen,Tieqiu Huang,Zhigang You,Yanqing Wu,Renqiang Yang
出处
期刊:Journal of Cardiovascular Pharmacology and Therapeutics [SAGE]
卷期号:28: 107424842311742-107424842311742 被引量:1
标识
DOI:10.1177/10742484231174296
摘要

Objective: To investigate the protective effect of nicorandil on contrast-induced acute kidney injury (CIAKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). Methods: This is a single-center, retrospective control study. A total of 156 patients with STEMI were divided into the nicorandil group (n = 55) and the control group (n = 101). The incidence of CIAKI, defined as an increase of >25% or absolute values > 44.2 μmol/L in serum creatinine (Scr) from baseline within 72 h of exposure to a contrast agent after exclusion of other causes, was the primary endpoint. The secondary endpoints were: (1) changes of Scr, estimated glomerular filtration rate (eGFR), uric acid, and β2-microglobulin at 24/48/72 h and 5 to 7 days after PCI; (2) the peak value difference of creatine kinase isoenzymes (CK-MB) after PCI; (3) adverse events within 6 months after PCI. Results: The overall incidence of CIAKI was 21.8%; the incidence of CIAKI in the nicorandil group was significantly lower (12.7% [7/55]) than in the control group (26.7% [27/101]) (P = .043). Compared with the control group, Scr, uric acid, and β2-microglobulin levels were lower, and the level of eGFR was higher in nicorandil group (P all < .05). The peak value of CK-MB in the nicorandil group was lower than that in the control group (105.30 [56.61, 232.04] vs 178.00 [77.08, 271.91]U/L, P = .042). There was no significant difference in adverse events between the 2 groups within 6 months after PCI. Moreover, multivariate logistic regression analysis showed that hypertension and diabetes were independent risk factors for CIAKI, while nicorandil treatment was a protective factor. Conclusion: Our data suggest that intravenous nicorandil after emergency PCI has a protective effect on the occurrence of CIAKI in STEMI patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xxz完成签到,获得积分10
1秒前
ding应助曾经天德采纳,获得30
1秒前
夏天发布了新的文献求助10
1秒前
李爱国应助海洋采纳,获得10
3秒前
bk2020113458完成签到,获得积分10
3秒前
4秒前
XiaohuLee完成签到,获得积分10
4秒前
吴正言完成签到,获得积分10
4秒前
4秒前
orixero应助buger采纳,获得10
7秒前
St雪发布了新的文献求助10
7秒前
璐洋完成签到,获得积分20
8秒前
zgy发布了新的文献求助10
8秒前
Orange应助时567采纳,获得10
9秒前
9秒前
领导范儿应助威武的士萧采纳,获得10
10秒前
共享精神应助起风了采纳,获得10
10秒前
111发布了新的文献求助10
10秒前
脑洞疼应助ureil采纳,获得10
10秒前
12秒前
ccmxigua完成签到,获得积分10
13秒前
13秒前
13秒前
wdn0411发布了新的文献求助10
13秒前
14秒前
15秒前
15秒前
海洋完成签到,获得积分20
15秒前
还行完成签到,获得积分10
16秒前
热心的匕应助小赵采纳,获得10
16秒前
17秒前
沉静海白完成签到,获得积分10
17秒前
曾经天德发布了新的文献求助30
17秒前
薰硝壤应助Ruiiiiii采纳,获得10
17秒前
18秒前
Sheep_ST完成签到,获得积分10
18秒前
赘婿应助zxj采纳,获得10
18秒前
19秒前
沉静海白发布了新的文献求助10
19秒前
xxz发布了新的文献求助10
19秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3135752
求助须知:如何正确求助?哪些是违规求助? 2786595
关于积分的说明 7778521
捐赠科研通 2442742
什么是DOI,文献DOI怎么找? 1298676
科研通“疑难数据库(出版商)”最低求助积分说明 625205
版权声明 600866