医学
内科学
肺癌
倾向得分匹配
阶段(地层学)
总体生存率
癌症
性能状态
肿瘤科
生物
古生物学
作者
Xiao‐mei Jing,Ping Chen,Sifeng Li,Zi‐rui Feng,Yinfeng Li,Qing Yang
摘要
Abstract Aim To evaluate the effect of multidisciplinary treatment (MDT) on the survival outcomes of Chinese lung cancer patients. Methods Data from a Chinese tertiary cancer hospital of lung cancer patients were collected and divided into two groups (MDT+/−) according to whether the patients had received an MDT. The survival analysis was performed after propensity score matching (PSM). Results Before PSM, more patients in the MDT+ group had documented information on clinical characteristics and showed more unfavorable clinical characteristics than patients in the MDT− group. After PSM, there was no imbalance in the first‐line treatment strategies between the two groups. When the patients were analyzed separately, for patients in the MDT− group, age at diagnosis, Eastern Cooperative Oncology Group (ECOG) score, stage, smoking history, and epidermal growth factor receptor (EGFR) gene status were all significant factors for survival ( p < 0.05). For patients in the MDT+ group, only age at diagnosis, stage, and comorbidities were significant factors for survival ( p < 0.05). Moreover, age at diagnosis, ECOG score, stage, EGFR gene status, and MDT were all significant factors for survival for all patients ( p < 0.001). The results indicate that MDT was a significant prognostic factor independent of clinical characteristics (HR: 2.095, 95% CI: 1.568–2.800, p < 0.001), with a significantly improved median survival (58.0 vs. 29.0 months, p < 0.001). Conclusion Based on PSM, MDT itself did have a real favorable prognostic significance for Chinese lung cancer patients in the study.
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