亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Residual insulin secretion in individuals with type 1 diabetes in Finland: longitudinal and cross-sectional analyses

医学 糖尿病 2型糖尿病 C肽 横断面研究 内科学 1型糖尿病 纵向研究 胰岛素 逻辑回归 方差分析 内分泌学 病理
作者
Minna Harsunen,Jani K. Haukka,Valma Harjutsalo,Nina Mars,Anna Syreeni,Taina Härkönen,Annemari Käräjämäki,Jorma Ilonen,Mikael Knip,Niina Sandholm,Päivi J. Miettinen,Per‐Henrik Groop,Jaakko Tuomilehto
出处
期刊:The Lancet Diabetes & Endocrinology [Elsevier BV]
卷期号:11 (7): 465-473 被引量:16
标识
DOI:10.1016/s2213-8587(23)00123-7
摘要

Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, many individuals with type 1 diabetes have circulating C-peptide years after the diagnosis. We studied factors affecting random serum C-peptide concentration in individuals with type 1 diabetes and the association with diabetic complications.Our longitudinal analysis included individuals newly diagnosed with type 1 diabetes from Helsinki University Hospital (Helsinki, Finland) with repeated random serum C-peptide and concomitant glucose measurements from within 3 months of diagnosis and at least once later. The long-term cross-sectional analysis included data from participants from 57 centres in Finland who had type 1 diabetes diagnosed after 5 years of age, initiation of insulin treatment within 1 year from diagnosis, and a C-peptide concentration of less than 1·0 nmol/L (FinnDiane study) and patients with type 1 diabetes from the DIREVA study. We tested the association of random serum C-peptide concentrations and polygenic risk scores with one-way ANOVA, and association of random serum C-peptide concentrations, polygenic risk scores, and clinical factors with logistic regression.The longitudinal analysis included 847 participants younger than 16 years and 110 aged 16 years or older. In the longitudinal analysis, age at diagnosis strongly correlated with the decline in C-peptide secretion. The cross-sectional analysis included 3984 participants from FinnDiane and 645 from DIREVA. In the cross-sectional analysis, at a median duration of 21·6 years (IQR 12·5-31·2), 776 (19·4%) of 3984 FinnDiane participants had residual random serum C-peptide secretion (>0·02 nmol/L), which was associated with lower type 1 diabetes polygenic risk compared with participants without random serum C-peptide (p<0·0001). Random serum C-peptide was inversely associated with hypertension, HbA1c, and cholesterol, but also independently with microvascular complications (adjusted OR 0·61 [95% CI 0·38-0·96], p=0·033, for nephropathy; 0·55 [0·34-0·89], p=0·014, for retinopathy).Although children with multiple autoantibodies and HLA risk genotypes progressed to absolute insulin deficiency rapidly, many adolescents and adults had residual random serum C-peptide decades after the diagnosis. Polygenic risk of type 1 and type 2 diabetes affected residual random serum C-peptide. Even low residual random serum C-peptide concentrations seemed to be associated with a beneficial complications profile.Folkhälsan Research Foundation; Academy of Finland; University of Helsinki and Helsinki University Hospital; Medical Society of Finland; the Sigrid Juselius Foundation; the "Liv and Hälsa" Society; Novo Nordisk Foundation; and State Research Funding via the Helsinki University Hospital, the Vasa Hospital District, Turku University Hospital, Vasa Central Hospital, Jakobstadsnejdens Heart Foundation, and the Medical Foundation of Vaasa.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xie完成签到 ,获得积分10
2秒前
zzz完成签到,获得积分10
9秒前
10秒前
刘明坤完成签到 ,获得积分10
10秒前
12秒前
12秒前
zhoux发布了新的文献求助10
13秒前
15秒前
上官若男应助ceeray23采纳,获得20
15秒前
研友_qZ6V1Z发布了新的文献求助10
17秒前
19秒前
星辰大海应助towerman采纳,获得10
21秒前
xutong de完成签到,获得积分10
24秒前
qpp完成签到,获得积分10
25秒前
三木足球完成签到,获得积分10
26秒前
zhoux完成签到,获得积分10
29秒前
coc完成签到,获得积分10
34秒前
34秒前
36秒前
36秒前
towerman发布了新的文献求助10
39秒前
上官若男应助研友_qZ6V1Z采纳,获得10
43秒前
FengyaoWang完成签到,获得积分10
43秒前
44秒前
enchanted发布了新的文献求助10
49秒前
ZHANG123完成签到,获得积分10
53秒前
1分钟前
七色光完成签到,获得积分10
1分钟前
1分钟前
1分钟前
ceeray23发布了新的文献求助20
1分钟前
爆米花应助Bowman采纳,获得30
1分钟前
1分钟前
研友_qZ6V1Z发布了新的文献求助10
1分钟前
1分钟前
shaylie完成签到 ,获得积分10
1分钟前
伽拉发布了新的文献求助10
1分钟前
轻松的惜芹应助linkman采纳,获得10
1分钟前
Karol发布了新的文献求助10
1分钟前
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532049
关于积分的说明 11256153
捐赠科研通 3270925
什么是DOI,文献DOI怎么找? 1805123
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216