神经科学
人脑
静息状态功能磁共振成像
神经影像学
精神病
转录组
心理学
神经功能成像
表型
生物
精神分裂症(面向对象编程)
默认模式网络
毒品天真
基因
功能磁共振成像
基因表达
遗传学
药品
精神科
作者
Qian Li,Xiaotao Xu,Yinfeng Qian,Huanhuan Cai,Wenming Zhao,Jiajia Zhu,Yongqiang Yu
标识
DOI:10.1038/s41537-023-00338-z
摘要
Abstract Extensive research has established the presence of resting-state brain functional damage in psychosis. However, the genetic mechanisms of such disease phenotype are yet to be unveiled. We investigated resting-state brain functional alterations in patients with drug-naive first-episode psychosis (DFP) by performing a neuroimaging meta-analysis of 8 original studies comprising 500 patients and 469 controls. Combined with the Allen Human Brain Atlas, we further conducted transcriptome-neuroimaging spatial correlations to identify genes whose expression levels were linked to brain functional alterations in DFP, followed by a range of gene functional characteristic analyses. Meta-analysis revealed a mixture of increased and decreased brain function in widespread areas including the default-mode, visual, motor, striatal, and cerebellar systems in DFP. Moreover, these brain functional alterations were spatially associated with the expression of 1662 genes, which were enriched for molecular functions, cellular components, and biological processes of the cerebral cortex, as well as psychiatric disorders including schizophrenia. Specific expression analyses demonstrated that these genes were specifically expressed in the brain tissue, in cortical neurons and immune cells, and during nearly all developmental periods. Concurrently, the genes could construct a protein-protein interaction network supported by hub genes and were linked to multiple behavioral domains including emotion, attention, perception, and motor. Our findings provide empirical evidence for the notion that brain functional damage in DFP involves a complex interaction of polygenes with various functional characteristics.
科研通智能强力驱动
Strongly Powered by AbleSci AI