The profile and prognostic value of circulating lymphocyte subsets in metastatic colon cancer

结直肠癌 克拉斯 医学 内科学 淋巴细胞 CD8型 肿瘤科 外周血淋巴细胞 癌症 比例危险模型 单变量分析 免疫学 多元分析 免疫系统
作者
Juan Xu,Ruru Zhang,Qing Peng,Zhenghu Jia,Shuang Xiao,Niangen Sun,Mengqing Peng
出处
期刊:International Immunopharmacology [Elsevier BV]
卷期号:117: 109848-109848 被引量:6
标识
DOI:10.1016/j.intimp.2023.109848
摘要

Colon cancer (CC) are the most common malignant cancer in human digestive system, however, the profile and prognostic value of circulating lymphocyte subsets in CC patients has not been systemically clarified.In this study, 158 patients with metastatic CC were enrolled. Chi-square test was used to analyze the relationship between baseline peripheral blood lymphocyte subsets and clinicopathological parameters. Kaplan-Meier and Log-rank tests were used to analyze the relationship between clinicopathological parameters and baseline peripheral lymphocyte subsets and overall survival (OS) of patients with metastatic CC. Univariate/multivariate COX regression analysis was used to identify the independent factors in metastatic CC.The baseline peripheral blood CD3+T cells, CD4+T cells, NK cells and B cells of BRAF mutant patients were significantly lower than those in BRAF wild-type patients; The baseline CD8+T cells of KRAS mutation group was lower than that in KRAS wild type group. Peripheral blood CA19-9 > 27, left-sided colon cancer (LCC), KRAS and BRAF mutation were poor prognostic factors, and ALB > 40, NK cells were protective prognostic factors for metastatic CC. In patients with liver metastases subgroup, higher NK cells also indicated a longer OS. Finally, LCC (HR = 0.56), CA19-9 (HR = 2.13), ALB (HR = 0.46) and circulating NK cells (HR = 0.55) were independent prognostic factors for metastatic CC.LCC, higher level of ALB and NK cells at baseline are protective factors, and higher CA19-9, KRAS/BRAF gene mutation are adverse prognostic factors. Sufficient circulating NK cells are independent prognostic factor for metastatic CC patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jsq完成签到,获得积分20
1秒前
1秒前
HuiHui完成签到,获得积分10
2秒前
酷波er应助晚风采纳,获得10
2秒前
zss完成签到,获得积分10
3秒前
踏实的道消完成签到 ,获得积分10
3秒前
ccx981166完成签到,获得积分10
5秒前
烟花应助木鸽子采纳,获得10
5秒前
7秒前
乐乐应助PLAGH221采纳,获得10
8秒前
未来可期发布了新的文献求助10
10秒前
13秒前
14秒前
14秒前
16秒前
17秒前
乐天发布了新的文献求助10
19秒前
疯狂的炳发布了新的文献求助10
19秒前
20秒前
Owen应助心灵美的修洁采纳,获得10
20秒前
21秒前
解语花发布了新的文献求助10
21秒前
23秒前
搜集达人应助科研通管家采纳,获得10
23秒前
23秒前
23秒前
23秒前
23秒前
Owen应助科研通管家采纳,获得10
23秒前
小马甲应助科研通管家采纳,获得10
23秒前
Hello应助科研通管家采纳,获得10
23秒前
李爱国应助科研通管家采纳,获得10
24秒前
桐桐应助科研通管家采纳,获得10
24秒前
JamesPei应助科研通管家采纳,获得10
24秒前
JamesPei应助科研通管家采纳,获得10
24秒前
慕青应助科研通管家采纳,获得10
24秒前
24秒前
24秒前
24秒前
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3967419
求助须知:如何正确求助?哪些是违规求助? 3512730
关于积分的说明 11164792
捐赠科研通 3247704
什么是DOI,文献DOI怎么找? 1793978
邀请新用户注册赠送积分活动 874785
科研通“疑难数据库(出版商)”最低求助积分说明 804517