骨重建
骨桥蛋白
医学
N-末端末端肽
内科学
骨钙素
内分泌学
骨硬化
全身性肥大细胞增多症
类胰蛋白酶
促炎细胞因子
细胞因子
骨保护素
病理
骨髓
免疫学
碱性磷酸酶
化学
炎症
肥大细胞
受体
酶
激活剂（遗传学）
生物化学
作者
Tiago Azenha Rama,Ana Henriques,Almudena Matito,María Jara‐Acevedo,Carolina Caldas,Andrea Mayado,Javier I. Muñoz‐González,André Moreira,João Cavaleiro Rufo,Andrés C. García‐Montero,Alberto Órfão,Laura Sánchez‐Muñoz,Iván Álvarez‐Twöse
标识
DOI：10.1016/j.jaip.2023.02.007
摘要
Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown.
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