转录组
再灌注损伤
肝损伤
缺血
肝移植
雷公藤醇
下调和上调
移植
缺血预处理
医学
生物
药理学
内科学
基因
基因表达
细胞凋亡
生物化学
作者
Jiaqi Xin,Ting Yang,Xiaoyi Wu,Yingting Wu,Yi Liu,Xuan Liu,Mengxi Jiang,Wei Gao
标识
DOI:10.1038/s42003-023-04564-0
摘要
Abstract Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. The connection between I/R-induced injury response and liver heterogeneity has yet to be fully understood. In this study, we converge histopathological examination with spatial transcriptomics to dissect I/R injury patterns and their associated molecular changes, which reveal that the pericentral zones are most sensitive to I/R injury in terms of histology, transcriptomic changes, and cell type dynamics. Bioinformatic analysis of I/R injury-related pathways predicts that celastrol can protect against liver I/R injury by inducing ischemic pre-conditioning, which is experimentally validated. Mechanistically, celastrol likely implements its protective effect against I/R injury by activating HIF1α signaling and represents a potential strategy for resolving liver I/R.
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