免疫佐剂
抗原
抗体
免疫学
免疫抑制
癌症
交叉展示
免疫系统
癌症疫苗
生物
抗原呈递
癌症研究
医学
免疫疗法
T细胞
遗传学
作者
Fangjie Chen,Mengmeng Zhang,Fengmin Yang,Lu Wang,Jinyao Liu,Junqiu Liu,Yan Pang
出处
期刊:Small
[Wiley]
日期:2023-12-01
卷期号:20 (17)
被引量:2
标识
DOI:10.1002/smll.202307748
摘要
Abstract As one of the most common complications, infection causes the majority of mortality in cancer patients. However, therapeutic strategies that can simultaneously suppress tumors and protect patients from infection have been rarely reported. Here, the use of dual‐antigen‐displaying nanovaccines (DADNs) is described to elicit synergistic immunoactivation for treating cancer and preventing infectious complications. DADNs are prepared by wrapping immunoadjuvant‐loaded nanoparticles with a hybrid coating, which is fused from cell membranes that are separately genetically engineered to express tumor and infectious pathogenic antigens. Due to the presence of a dual‐antigen combination, DADNs are able to promote the maturation of dendritic cells and more importantly to trigger cross‐presentation of both combined antigens. During in vivo investigations, we find that DADNs can reverse immunosuppression by stimulating tumor‐associated antigen‐specific T‐cell responses, resulting in significantly delayed tumor growth in mice. These nanovaccines also elicit effective protective immunity against tumor challenges and induce robust production of pathogenic antigen‐specific immunoglobulin G antibody in a prophylactic study. This work offers a unique approach to develop dual‐mode vaccines, which are promising for synchronously treating cancer and preventing infection.
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