曲折
有效扩散系数
渗透(HVAC)
血脑屏障
药物输送
生物物理学
纳米技术
星形胶质细胞
材料科学
细胞外
化学
细胞生物学
神经科学
医学
中枢神经系统
生物
癌症研究
有机化学
多孔性
磁共振成像
复合材料
放射科
作者
Hejian Xiong,Blake A. Wilson,Xiaoqian Ge,Xiaofei Gao,Qi Cai,Xueqi Xu,Robert Bachoo,Zhenpeng Qin
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-01-29
卷期号:24 (5): 1570-1578
标识
DOI:10.1021/acs.nanolett.3c04101
摘要
Glioblastoma (GBM) is the most complex and lethal primary brain cancer. Adequate drug diffusion and penetration are essential for treating GBM, but how the spatial heterogeneity in GBM impacts drug diffusion and transport is poorly understood. Herein, we report a new method, photoactivation of plasmonic nanovesicles (PANO), to measure molecular diffusion in the extracellular space of GBM. By examining three genetically engineered GBM mouse models that recapitulate key clinical features including the angiogenic core and diffuse infiltration, we found that the tumor margin has the lowest diffusion coefficient (highest tortuosity) compared with the tumor core and surrounding brain tissue. Analysis of the cellular composition shows that tortuosity in the GBM is strongly correlated with neuronal loss and astrocyte activation. Our all-optical measurement reveals the heterogeneous GBM microenvironment and highlights the tumor margin as a diffusion barrier for drug transport in the brain, with implications for therapeutic delivery.
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