Rheumatoid Arthritis: The Continuum of Disease and Strategies for Prediction, Early Intervention, and Prevention

医学 类风湿性关节炎 观察研究 临床试验 自然史 重症监护医学 疾病 生物标志物 干预(咨询) 关节炎 物理疗法 内科学 生物化学 化学 精神科
作者
Liam J. O’Neil,D. Alpizar-Rodriguez,Kevin D. Deane
出处
期刊:The Journal of Rheumatology [The Journal of Rheumatology]
卷期号:51 (4): 337-349
标识
DOI:10.3899/jrheum.2023-0334
摘要

Rheumatoid arthritis (RA) is known to include a pre-RA stage that can be defined as the presence of familial or genetic risk factors, biomarker abnormalities (eg, anticitrullinated protein antibodies [ACPA]), symptoms, and even abnormal imaging findings prior to the development of the onset of clinical RA with inflammatory arthritis that is apparent on physical examination. Indeed, there are multiple completed or ongoing retrospective case-control as well as prospective observational studies to identify the key biologic drivers of disease. Further, building on the predictive ability of combinations of biomarkers, symptoms, and imaging for future RA, there are multiple clinical trials completed, underway, or in development to identify approaches that may prevent, delay, or ameliorate future clinical RA in at-risk individuals. Importantly, however, although an effective preventive intervention has not yet been identified, at-risk individuals are being increasingly identified in clinical care; this presents a challenge of how to manage these individuals in clinical practice. This review will discuss the current understanding of the biology and natural history of RA development, nomenclature, and current models for prediction of future RA, as well as evaluate the current and ongoing clinical prevention trials with the overall goal to provide insights into the challenges and opportunities in the field of RA prevention. Moreover, this review will provide up-to-date options for clinical management of individuals at risk for RA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_8K2lBZ完成签到,获得积分10
刚刚
1秒前
3秒前
4秒前
4秒前
lichunrong发布了新的文献求助10
4秒前
6秒前
兴奋元冬发布了新的文献求助10
6秒前
9秒前
Gzl完成签到 ,获得积分10
12秒前
12秒前
Beautieat1发布了新的文献求助30
15秒前
16秒前
琦趣q发布了新的文献求助10
16秒前
风吹发布了新的文献求助10
18秒前
18秒前
悲凉的雪晴完成签到,获得积分20
20秒前
20秒前
Cosima完成签到 ,获得积分10
20秒前
20秒前
黑凤雷完成签到,获得积分10
22秒前
陈寯完成签到,获得积分10
22秒前
haipronl应助ning采纳,获得20
22秒前
23秒前
23秒前
24秒前
Hhhhh发布了新的文献求助10
25秒前
顾矜应助李昕123采纳,获得10
26秒前
元66666完成签到 ,获得积分10
27秒前
斯文败类应助FF采纳,获得10
28秒前
minibearQ完成签到,获得积分10
28秒前
斯文败类应助科研通管家采纳,获得10
29秒前
所所应助威威采纳,获得10
29秒前
爆米花应助科研通管家采纳,获得10
29秒前
今后应助科研通管家采纳,获得10
29秒前
852应助科研通管家采纳,获得10
29秒前
爆米花应助科研通管家采纳,获得10
29秒前
搜集达人应助科研通管家采纳,获得10
29秒前
薰硝壤应助科研通管家采纳,获得10
29秒前
琦趣q完成签到,获得积分10
29秒前
高分求助中
LNG地下式貯槽指針(JGA指-107-19)(Recommended practice for LNG inground storage) 1000
rhetoric, logic and argumentation: a guide to student writers 1000
QMS18Ed2 | process management. 2nd ed 1000
Eric Dunning and the Sociology of Sport 850
Operative Techniques in Pediatric Orthopaedic Surgery 510
Generalized Linear Mixed Models 第二版 500
人工地层冻结稳态温度场边界分离方法及新解答 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2921247
求助须知:如何正确求助?哪些是违规求助? 2563725
关于积分的说明 6934612
捐赠科研通 2221509
什么是DOI,文献DOI怎么找? 1180831
版权声明 588787
科研通“疑难数据库(出版商)”最低求助积分说明 577730