慢性粒细胞白血病
医学
髓系白血病
造血
数字聚合酶链反应
骨髓
肿瘤科
注意事项
分子诊断学
生物信息学
白血病
内科学
干细胞
聚合酶链反应
病理
生物
基因
生物化学
遗传学
作者
Meenakshi Pinnenti,Muhammad Ahsan Sami,Umer Hassan
出处
期刊:Biomicrofluidics
[American Institute of Physics]
日期:2024-01-01
卷期号:18 (1)
摘要
Chronic myelogenous/myeloid leukemia (CML) is a type of cancer of bone marrow that arises from hematopoietic stem cells and affects millions of people worldwide. Eighty-five percent of the CML cases are diagnosed during chronic phase, most of which are detected through routine tests. Leukocytes, micro-Ribonucleic Acids, and myeloid markers are the primary biomarkers for CML diagnosis and are mainly detected using real-time reverse transcription polymerase chain reaction, flow cytometry, and genetic testing. Though multiple therapies have been developed to treat CML, early detection still plays a pivotal role in the overall patient survival rate. The current technologies used for CML diagnosis are costly and are confined to laboratory settings which impede their application in the point-of-care settings for early-stage detection of CML. This study provides detailed analysis and insights into the significance of CML, patient symptoms, biomarkers used for testing, and best possible detection techniques responsible for the enhancement in survival rates. A critical and detailed review is provided around potential microfluidic devices that can be adapted to detect the biomarkers associated with CML while enabling point-of-care testing for early diagnosis of CML to improve patient survival rates.
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