医学
介绍(产科)
病理
上皮样血管内皮瘤
血管瘤
肿瘤
血管内皮瘤
皮肤病科
放射科
免疫组织化学
作者
Siddhartha Dash,Biswanath Behera,Parvathy Viswan,Kunal Garg,Madhusmita Sethy,Pavithra Ayyanar
出处
期刊:American Journal of Dermatopathology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-02-07
卷期号:46 (4): 232-234
被引量:1
标识
DOI:10.1097/dad.0000000000002625
摘要
Abstract: Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor that comprises less than 1% of all vascular tumors. Cutaneous involvement in EHE can occur either by spreading from underlying bone or rarely could be limited to the skin and mostly presents as solitary well-circumscribed mass to an ill-defined infiltrative lesion. We present a case of rapidly progressive and debilitating EHE presenting multiple vascular papules and nodules. Histopathology showed an ill-circumscribed nodular proliferation of epithelioid and spindled cells in the dermis that extended into the subcutaneous tissue. The tumor cells had moderate eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli. In addition, they showed evidence of lumen formation and intracytoplasmic vacuoles. Brisk mitosis was noted. On immunohistochemistry, the cells were strongly positive for CD31, CD34, and ERG (ETS [erythroblast transformation-specific]-related gene). MIB-1 labeling index was more than 75% in the highest proliferating areas. A high degree of clinical suspicion and immunopathological examination is recommended for early diagnosis of this rare condition before it becomes function or life-threatening.
科研通智能强力驱动
Strongly Powered by AbleSci AI