单宁酸
抗氧化剂
胶束
氧化应激
化学
药物输送
材料科学
纳米技术
组合化学
有机化学
生物化学
水溶液
作者
Fengying Dai,Kangle Lv,Bo Zhang,Junqiang Zhao,Shaoteng Wang,Ke Lan,Yiping Zhao,Xiaolei Zhang,Bohong Kan
出处
期刊:Biomaterials advances
日期:2023-11-01
卷期号:154: 213651-213651
被引量:1
标识
DOI:10.1016/j.bioadv.2023.213651
摘要
Tannic acid (TA) shell is of great interest for nanodrug design due to its versatile application such as antioxidant, antibacterial, anti-inflammatory. However, evidence is emerging that TA air oxidation in storage stage and unfavorable interactions of TA with electrolyte or protein in drug delivery could bring great challenge for the structure stability of nanodrug. In this study, a smart TA shell of nanomicelles was constructed through phenolic hydroxyl protection strategy, and the antioxidant capacity of nanomicelles maintain stable after 24 days storage. The phenolic hydroxyl protective tannic acid micelles (PHPTA micelles) show excellent performance for combination delivery of azoramide (Azo), dantrolene (Dan), Trazodone (Tra) in accelerated senescence (SAMP8) mice. This study may pave the way for the fabrication of nanodrugs with stable and smart TA shell for oxidative stress relevant diseases.
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