Impaired Sensitivity to Thyroid Hormones Is Associated With Decreased Vitamin D Levels in the Euthyroid Population

甲状腺机能正常 内科学 内分泌学 甲状腺 医学 维生素D与神经学 激素 体质指数 背景(考古学) 人口 促甲状腺激素 生物 环境卫生 古生物学
作者
Yuanmeng Li,Juan Sun,Yang Jiao,Naishi Li,Weigang Zhao
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
卷期号:109 (3): 691-700 被引量:4
标识
DOI:10.1210/clinem/dgad607
摘要

Abstract Context The relationship between vitamin D and thyroid profiles lacks consensus despite extensive investigations. Whether vitamin D levels correlate with thyroid hormone sensitivity remains largely unexplored. Objective To explore the relationship between vitamin D levels and thyroid hormone sensitivity among euthyroid individuals. Methods This study involved 6452 euthyroid participants. Clinical parameters, including TSH, free thyroxine, 25-hydroxyvitamin D [25(OH)D], and other relevant indicators were extracted from the National Health and Nutrition Examination Survey 2007-2012. To quantify thyroid hormone sensitivity, we calculated the Thyroid Feedback Quantile-based Index (TFQI), the TSH index (TSHI), and the thyrotropin thyroxine resistance index (TT4RI). Results Subjects with impaired thyroid hormone sensitivity have decreased 25(OH)D levels (TFQI, TT4RI: P < 0.05; TSHI: P = .05574) following adjustment of confounding variables. Age-specific analysis found negative correlations between thyroid hormone sensitivity indices and 25(OH)D within the 20 to 60 years subgroup, turning positive in the 60 to 80 years subgroup. In females, thyroid hormone sensitivity indices and vitamin D levels were negatively linked, while in males, vitamin D's relationships with TFQI, TT4RI, and TSHI shifted from negative to positive when 25(OH)D levels exceeded 63.5 nmol/L, 56.7 nmol/L, and 56.7 nmol/L, respectively. Stratification by race revealed U-shaped curvilinear patterns resembling those found in the males. In body mass index (BMI) subanalysis, vitamin D had differing associations with thyroid hormone sensitivity indices: negative in the <25 kg/m2 and ≥30 kg/m2 subgroups and U-shaped in the 25-30 kg/m2 subgroup. Conclusion Impaired thyroid hormone sensitivity correlates with decreased vitamin D levels among euthyroid subjects, with associations varying by age, sex, race, and BMI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
2秒前
orixero应助薛之谦采纳,获得10
3秒前
jackmilton完成签到,获得积分10
3秒前
qweerrtt发布了新的文献求助30
4秒前
王一越关注了科研通微信公众号
4秒前
完美世界应助wild_yawp采纳,获得10
5秒前
莫离完成签到 ,获得积分10
5秒前
Lucas应助qiuli采纳,获得10
5秒前
5秒前
6秒前
赵焱峥发布了新的文献求助10
6秒前
6秒前
jackmilton发布了新的文献求助10
7秒前
斯文败类应助kurtlin采纳,获得10
7秒前
娴娴超爱笑完成签到,获得积分10
7秒前
心灵美的幻姬完成签到,获得积分10
8秒前
半柚应助苏苏采纳,获得10
8秒前
Lin应助依旧采纳,获得10
9秒前
涵泽发布了新的文献求助10
10秒前
coolkid完成签到 ,获得积分10
12秒前
12秒前
14秒前
大个应助chenying采纳,获得10
15秒前
16秒前
16秒前
Lian完成签到,获得积分10
17秒前
小陈发布了新的文献求助10
17秒前
17秒前
诶诶完成签到,获得积分10
18秒前
19秒前
20秒前
Lian发布了新的文献求助10
20秒前
alexlpb完成签到,获得积分0
20秒前
王一越发布了新的文献求助10
20秒前
WU完成签到,获得积分10
21秒前
chuckle发布了新的文献求助10
21秒前
Ekko完成签到,获得积分10
21秒前
22秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Am Rande der Geschichte : mein Leben in China / Ruth Weiss 1500
CENTRAL BOOKS: A BRIEF HISTORY 1939 TO 1999 by Dave Cope 1000
Machine Learning Methods in Geoscience 1000
Resilience of a Nation: A History of the Military in Rwanda 888
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3737910
求助须知:如何正确求助?哪些是违规求助? 3281470
关于积分的说明 10025533
捐赠科研通 2998170
什么是DOI,文献DOI怎么找? 1645135
邀请新用户注册赠送积分活动 782612
科研通“疑难数据库(出版商)”最低求助积分说明 749843