Correlation between hs-CRP, VCAM-1, LEP levels and blood pressure variability in OSAHS patients

This study was to explore the relationship between hs-CRP, VCAM-1, LEP and blood pressure variability in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. For this purpose, 92 OSAHS patients treated in our hospital from January 2019 to December 2022 were randomly divided into a mild group (MIG) (AHI > 5, < 20), moderate group (MOG) (AHI > 20 and not more than 40) and severe group (SEG) (AHI > 40). According to sleep AHI, they were divided into MIG (n = 28), MOG (n = 30) and SEG (n = 26). The age and sex of the patients in the study group were compared with those in the control group (COG). The serum levels of hs-CRP, VCAM-1, LEP and blood pressure variability were observed and compared. Pearson correlation test was used to analyze the correlation between hs-CRP, VCAM-1, LEP levels and blood pressure variability in patients with OSAHS. Results showed that the age, sex and BMI between each group have no difference(P>0.05), but the AHI in the study group was raised than that in the COG (P<0.05). Compared with the COG, the serum levels of hs-CRP, VCAM-1, LEP and dDBP, dSBP, nDBP and nSBPraised with the increase of the severity of the disease (P<0.05). The dDBP among MOG, MIG and SEG was no different (P>0.05). The blood pressure variability of patients with OSAHS was raised, especially at night. Pearson correlation test showed that nSBP was positively correlated with serum levels of hs-CRP, VCAM-1 and LEP, that is, blood pressure variability was positively correlated with serum levels of hs-CRP, VCAM-1 and LEP (P<0.05). In conclusion, the serum levels of hs-CRP, VCAM-1 and LEP in patients with OSAHS are raised than those in healthy subjects, and they are significantly correlated with blood pressure variability, which can be used as an important index to judge the severity of OSAHS.