[Association between sleep quality/physical activity and metabolic syndrome in urban population of Xinjiang].

Objective: To explore the relationship between sleep/physical activity and metabolic syndrome (MS) in urban population of Xinjiang. Methods: This is a prospective, cross-sectional study. From July 2019 to September 2021, a two-stage random sampling method was used to randomly select residents aged 30-74 years from two communities in Urumqi of northern Xinjiang and Korla of southern Xinjiang. General situation questionnaire, Pittsburgh Sleep Quality Index Scale (PSQI) survey, International Physical Activity Questionnaire (IPAQ) survey, physical examination, physiological and biochemical indicators were obtained and analyzed. The dose-response curves of healthy sleep score and physical activity with metabolic syndrome were plotted using restricted cubic spline curves. Multivariate logistic regression model was used to analyze the independent and combined effects of sleep quality and physical activity on MS risk. Results: A total of 10 209 participants were included. The mean age of the subjects was (47.1±9.1) years, and males accounted for 51.3% (5 275/10 209). The prevalence of MS was significantly associated with the healthy sleep score and physical activity. Compared to the subjects with healthy sleep, OR (95%CI) of MS with intermediate, and poor sleep were 1.20(1.06-1.35), 1.23(1.04-1.45), respectively. Compared to the subjects with high physical activity, OR (95%CI) of MS with medium, low physical activity was 1.34(1.15-1.56), 1.42(1.19-1.70), respectively. There was a significant interaction between sleep and physical activity in MS (P for interaction=0.002). Compared to the subjects with high physical activity and healthy sleep, OR (95%CI) of MS with poor sleep and high physical activity was 2.03 (1.24-3.33, P for trend=0.016). Conclusion: Poor sleep quality and lack of physical activity are not only independent risk factors for an increased risk of MS but also have a combined effect with an increased risk of MS.目的： 探讨新疆地区城市人口睡眠质量和体力活动水平与代谢综合征（MS）患病的关联。 方法： 本研究为前瞻性、横断面研究。2019年7月至2021年9月采用两阶段随机抽样的方法随机选取北疆乌鲁木齐市、南疆库尔勒市2个固定社区30~74岁的居民，进行一般情况问卷调查、匹兹堡睡眠质量指数量表（PSQI）调查、国际体力活动问卷（IPAQ）调查、体格检查、生理生化指标检测。采用限制性立方样条曲线分别绘制睡眠质量和体力活动水平与MS患病的剂量-反应曲线。采用多因素logistic回归模型分析睡眠质量和体力活动水平与MS患病的独立及联合作用。 结果： 共纳入10 209名参与者，年龄（47.1±9.1）岁，男性占比51.3%（5 275/10 209）。健康睡眠得分、体力活动强度与MS患病呈线性关系。在睡眠质量中，与健康组相比，中等组、较差组患MS的风险增加，OR值（95%CI）分别为1.20（1.06~1.35）、1.23（1.04~1.45）。在体力活动水平中，与高水平组相比，中水平组、低水平组患MS的风险增加，OR值（95%CI）分别为1.34（1.15~1.56）、1.42（1.19~1.70）。睡眠质量与体力活动水平在MS患病中存在显著的交互作用（交互项P值=0.002），与体力活动高水平、睡眠质量较好的参与者相比，即使处于高体力活动水平，如睡眠质量较差，MS的患病风险依然增加（趋势性P值=0.016），OR值（95%CI）为2.03（1.24~3.33）。 结论： 睡眠质量差和缺乏体力活动，不仅是MS患病风险增加的独立危险因素，同时与MS患病风险增加存在联合作用。.