Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema

HomeCirculationVol. 148, No. 16Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextSphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema Ebba Brakenhielm Ebba BrakenhielmEbba Brakenhielm Correspondence to: Ebba Brakenhielm, Inserm UMR1096, Normandy University, UniRouen, Faculty of Medicine, 22 Boulevard Gambetta, Rouen, France. Email E-mail Address: [email protected] https://orcid.org/0000-0003-3378-8300 Rouen Institute for Innovation and Research in Biomedicine, INSERM EnVI UMR1096, University of Rouen Normandy, France. Search for more papers by this author Originally published16 Oct 2023https://doi.org/10.1161/CIRCULATIONAHA.123.066578Circulation. 2023;148:1250–1253This article is a commentary on the followingAbnormal Lymphatic Sphingosine-1-Phosphate Signaling Aggravates Lymphatic Dysfunction and Tissue InflammationFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Disclosures, see page 1253.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ebba Brakenhielm, Inserm UMR1096, Normandy University, UniRouen, Faculty of Medicine, 22 Boulevard Gambetta, Rouen, France. Email Ebba.Brakenhielm@inserm.frREFERENCES1. Brakenhielm E, Alitalo K. Cardiac lymphatics in health and disease.Nat Rev Cardiol. 2019; 16:56–68. doi: 10.1038/s41569-018-0087-8CrossrefMedlineGoogle Scholar2. Oliver G, Kipnis J, Randolph GJ, Harvey NL. 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Houssari M, Dumesnil A, Tardif V, Kivelä R, Pizzinat N, Boukhalfa I, Godefroy D, Schapman D, Hemanthakumar KA, Bizou M, et al. Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction.Arterioscler Thromb Vasc Biol. 2020; 40:1722–1737. doi: 10.1161/ATVBAHA.120.314370LinkGoogle Scholar15. Mehrara BJ, Park HJ, Kataru RP, Bromberg J, Coriddi M, Baik JE, Shin J, Li C, Cavalli MR, Encarnacion EM, et al. Pilot study of anti-Th2 immunotherapy for the treatment of breast cancer-related upper extremity lymphedema.Biology. 2021; 10:934. doi: 10.3390/biology10090934CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. 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Circulation. 2023;148:1231-1249 October 17, 2023Vol 148, Issue 16 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.066578PMID: 37844150 Originally publishedOctober 16, 2023 KeywordsT-lymphocyteslymphedemacytokinesendothelial cellsEditorialsinflammationPDF download Advertisement SubjectsEndothelium/Vascular Type/Nitric OxideInflammationLipids and CholesterolTranslational StudiesVascular Disease