Mucoadhesive chitosan microcapsules for controlled gastrointestinal delivery and oral bioavailability enhancement of low molecular weight peptides

生物利用度 化学 壳聚糖 光老化 口服 抗氧化剂 体内 药理学 最大值 控制释放 药代动力学 生物化学 医学 生物技术 皮肤病科 生物
作者
Kyungjik Yang,Hwa Seung Han,Seung Hwan An,Kyung Hoon Park,Keonwook Nam,Shinha Hwang,Yuyeon Lee,Sung Yeon Cho,Taehyung Kim,Deokyeong Choe,Sang Won Kim,Wonkyu Yu,Hyun Ah Lee,Jiyong Park,SangGuan You,Dong‐Gyu Jo,Ki Young Choi,Young Hoon Roh,Jae Hyung Park
出处
期刊:Journal of Controlled Release [Elsevier BV]
卷期号:365: 422-434 被引量:12
标识
DOI:10.1016/j.jconrel.2023.10.021
摘要

A bioactive compound, collagen peptide (CP), is widely used for biological activities such as anti-photoaging and antioxidant effects, with increased oral bioavailability because of its low molecular weight and high hydrophilicity. However, controlling release time and increasing retention time in the digestive tract for a more convenient oral administration is still a challenge. We developed CP-loaded chitosan (CS) microcapsules via strong and rapid ionic gelation using a highly negative phytic acid (PA) crosslinker. The platform enhanced the oral bioavailability of CP with controlled gastrointestinal delivery by utilizing the mucoadhesiveness and tight junction-opening properties of CS. CS and CP concentrations varied from 1.5 to 3.5% and 0–30%, respectively, for optimal and stable microcapsule synthesis. The physicochemical properties, in vitro release profile with intestinal permeability, in vivo oral bioavailability, in vivo biodistribution, anti-photoaging effect, and antioxidant effect of optimized CS microcapsules were analyzed to investigate the impact of controlling parameters. The structure of CS microcapsules was tuned by PA diffused gradient ionic cross-linking degree, resulting in a controlled CP release region in the gastrointestinal tract. The optimized microcapsules increased Cmax, AUC, and tmax by 1.5-, 3.4-, and 8.0-fold, respectively. Furthermore, CP in microcapsules showed anti-photoaging effects by downregulating matrix metalloproteinases-1 via antioxidant effects. According to our knowledge, this is the first study to microencapsulate CP for oral bioavailability enhancement. The peptide delivery method employed is simple, economical, and can be applied to customize bioactive compound administration.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
清歌浊酒完成签到,获得积分20
刚刚
jay发布了新的文献求助10
1秒前
热情鹤发布了新的文献求助30
3秒前
香蕉觅云应助帅男采纳,获得30
3秒前
4秒前
7秒前
小二郎应助wenlin采纳,获得10
8秒前
星辰大海应助大喵采纳,获得10
10秒前
11秒前
12秒前
天天快乐应助xxxllllll采纳,获得30
12秒前
小马甲应助amai采纳,获得10
13秒前
13秒前
热情鹤完成签到,获得积分10
14秒前
方便面了吗完成签到,获得积分20
15秒前
15秒前
15秒前
李健的小迷弟应助llllhh采纳,获得10
16秒前
今夜有雨完成签到 ,获得积分10
17秒前
17秒前
17秒前
17秒前
wenlin发布了新的文献求助10
19秒前
王武聪关注了科研通微信公众号
20秒前
peterlee发布了新的文献求助10
21秒前
wish发布了新的文献求助10
21秒前
风清扬应助慈祥的水池采纳,获得50
23秒前
大喵发布了新的文献求助10
23秒前
26秒前
27秒前
28秒前
29秒前
自觉绿草发布了新的文献求助10
30秒前
30秒前
ioio发布了新的文献求助10
31秒前
31秒前
wenlin完成签到,获得积分10
31秒前
amai发布了新的文献求助10
32秒前
许子健发布了新的文献求助10
32秒前
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531914
关于积分的说明 11255516
捐赠科研通 3270597
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190