已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Integrated Analysis of Metabolomics Combined with Network Pharmacology and Molecular Docking Reveals the Effects of Processing on Metabolites of Dendrobium officinale

代谢组学 代谢物 石斛 化学 计算生物学 药理学 传统医学 生物 生物化学 植物 色谱法 医学
作者
Lilan Xu,Si-Min Zuo,Mei Liu,Tao Wang,Zizheng Li,Yong‐Huan Yun,Weimin Zhang
出处
期刊:Metabolites [Multidisciplinary Digital Publishing Institute]
卷期号:13 (8): 886-886 被引量:1
标识
DOI:10.3390/metabo13080886
摘要

Dendrobium officinale (D. officinale) is a precious medicinal species of Dendrobium Orchidaceae, and the product obtained by hot processing is called “Fengdou”. At present, the research on the processing quality of D. officinale mainly focuses on the chemical composition indicators such as polysaccharides and flavonoids content. However, the changes in metabolites during D. officinale processing are still unclear. In this study, the process was divided into two stages and three important conditions including fresh stems, semiproducts and “Fengdou” products. To investigate the effect of processing on metabolites of D. officinale in different processing stages, an approach of combining metabolomics with network pharmacology and molecular docking was employed. Through UPLC-MS/MS analysis, a total of 628 metabolites were detected, and 109 of them were identified as differential metabolites (VIP ≥ 1, |log2 (FC)| ≥ 1). Next, the differential metabolites were analyzed using the network pharmacology method, resulting in the selection of 29 differential metabolites as they have a potential pharmacological activity. Combining seven diseases, 14 key metabolites and nine important targets were screened by constructing a metabolite–target–disease network. The results showed that seven metabolites with potential anticoagulant, hypoglycemic and tumor-inhibiting activities increased in relative abundance in the “Fengdou” product. Molecular docking results indicated that seven metabolites may act on five important targets. In general, processing can increase the content of some active metabolites of D. officinale and improve its medicinal quality to a certain extent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
shuhaha完成签到,获得积分10
1秒前
开朗小兔子完成签到,获得积分10
3秒前
共享精神应助qiu采纳,获得10
4秒前
9秒前
zhuxuanfeng发布了新的文献求助10
11秒前
烟花应助hxt采纳,获得10
18秒前
18秒前
生动丑应助科研通管家采纳,获得10
22秒前
22秒前
李爱国应助科研通管家采纳,获得10
22秒前
吱吱吱完成签到 ,获得积分10
25秒前
25秒前
25秒前
随性随缘随命完成签到 ,获得积分10
30秒前
水若琳发布了新的文献求助10
30秒前
31秒前
pluto应助qiu采纳,获得10
31秒前
32秒前
刮刮粉儿完成签到,获得积分10
32秒前
Alex完成签到,获得积分0
32秒前
YJL完成签到 ,获得积分10
34秒前
Alex发布了新的文献求助3000
36秒前
power完成签到,获得积分10
37秒前
hxt发布了新的文献求助10
38秒前
tttt完成签到 ,获得积分10
39秒前
Dr_Stars完成签到,获得积分10
39秒前
旷野发布了新的文献求助10
41秒前
42秒前
不去明知山完成签到 ,获得积分10
50秒前
环走鱼尾纹完成签到 ,获得积分10
50秒前
123完成签到 ,获得积分10
51秒前
善学以致用应助muyangsiyuan采纳,获得10
51秒前
甜蜜发带完成签到 ,获得积分10
53秒前
Honor完成签到 ,获得积分10
53秒前
鹿小新完成签到 ,获得积分0
54秒前
Jasper应助sunchengcehng采纳,获得10
54秒前
恣意完成签到 ,获得积分10
55秒前
笑笑完成签到 ,获得积分10
57秒前
hxt完成签到,获得积分10
1分钟前
研友_VZG7GZ应助水若琳采纳,获得10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989989
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11256053
捐赠科研通 3270900
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216