Past and Future Directions for Research on Cellular Senescence

Yi Zhu1,2, Zacharias P. Anastasiadis3, Jair Machado Espindola Netto2, Tamara Evans2, Tamar Tchkonia1,2 and James L. Kirkland1,4 1Department of Physiology and Biomedical Engineering, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA; 2Robert and Arlene Kogod Center on Aging, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA; 3Department of Biochemistry and Molecular Biology, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA; 4Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA Correspondence: kirkland.james{at}mayo.edu