Association between oocyte donors’ or recipients’ body mass index and clinical outcomes after first single blastocyst transfers—the uterus is the most affected

体重不足 医学 胚泡移植 流产 胚泡 活产 产科 妇科 怀孕 优势比 胚胎移植 体质指数 体外受精 超重 内科学 生物 胚胎 细胞生物学 胚胎发生 遗传学
作者
Gemma Fabozzi,Danilo Cimadomo,Roberta Maggiulli,Alberto Vaiarelli,Vicente Badajoz,Monica Aura,Stefano Canosa,Francesca Bongioanni,Francesca Benini,C Livi,Carlotta Zacà,Andrea Borini,Erminia Alviggi,Benedetta Iussig,María Hebles,Pascual Sànchez,Valentino Cimadomo,Laura Rienzi,J. Llácer
出处
期刊:Fertility and Sterility [Elsevier BV]
卷期号:121 (2): 281-290 被引量:6
标识
DOI:10.1016/j.fertnstert.2023.07.029
摘要

Objective To assess whether high body mass index (BMI) in either oocyte donors or recipients is associated with poorer outcomes after the first single blastocyst transfer. Design Retrospective study including 1,394 first blastocyst single embryo transfers (SETs) conducted by 1,394 recipients during oocyte donation cycles with the gametes retrieved from 1,394 women (January 2019–July 2021). Four BMI clusters were defined for both donors and recipients (underweight: <18.5 kg; normal weight: 18.5–24.9 kg; overweight: 25–29.9 kg; and obese: ≥30 kg). Setting Network of private IVF centers. Patients A total of 1,394 recipients aged 42.4 ± 4.0 and with a BMI of 23.2 ± 3.8 kg/m2, and 1,394 donors aged 26.1 ± 4.2 and with a BMI of 21.9 ± 2.5 kg/m2. Intervention All oocytes were vitrified at 2 egg banks and warmed at 8 in vitro fertilization clinics that were part of the same network. Intracytoplasmic sperm injection, blastocyst culture, and either fresh or vitrified-warmed SETs were conducted. Putative confounders were investigated, and the data were adjusted through regression analyses. Main Outcome Measures The primary outcome was the live birth rate (LBR) per SET according to donors' and/or recipients' BMI. The main secondary outcome was the miscarriage rate (<22 gestational weeks) per clinical pregnancy. Results The LBR per blastocyst SET showed no significant association with donors' BMI. Regarding recipients' BMI, instead, the multivariate odds ratio was significant in obese vs. normal-weight recipients (0.58, 95% confidence interval, 0.37–0.91). The miscarriage rate per clinical pregnancy was also significantly associated with recipients' obesity, with a multivariate odds ratio of 2.31 (95% confidence interval, 1.18–4.51) vs. normal-weight patients. A generalized additive model method was used to represent the relationship between predicted LBR or miscarriage rates and donors' or recipients' BMI; it pictured a scenario where the former outcome moderately but continuously decreases with increasing recipients' BMI to then sharply decline in the BMI range of 25–35 kg/m2. The miscarriage rate, instead, increases almost linearly with respect to both donors' and recipients' increasing BMI. Conclusion Obesity mostly affects the uterus, especially because of higher miscarriage rates. Yet, poorer outcomes can be appreciated already with a BMI of 25 kg/m2 in both oocyte donors and recipients. Finer markers of nutritional homeostasis are therefore desirable; recipients should be counseled about poorer expected outcomes in cases of overweight and obesity; and oocyte banks should avoid assigning oocytes from overweight donors to overweight and obese recipients. To assess whether high body mass index (BMI) in either oocyte donors or recipients is associated with poorer outcomes after the first single blastocyst transfer. Retrospective study including 1,394 first blastocyst single embryo transfers (SETs) conducted by 1,394 recipients during oocyte donation cycles with the gametes retrieved from 1,394 women (January 2019–July 2021). Four BMI clusters were defined for both donors and recipients (underweight: <18.5 kg; normal weight: 18.5–24.9 kg; overweight: 25–29.9 kg; and obese: ≥30 kg). Network of private IVF centers. A total of 1,394 recipients aged 42.4 ± 4.0 and with a BMI of 23.2 ± 3.8 kg/m2, and 1,394 donors aged 26.1 ± 4.2 and with a BMI of 21.9 ± 2.5 kg/m2. All oocytes were vitrified at 2 egg banks and warmed at 8 in vitro fertilization clinics that were part of the same network. Intracytoplasmic sperm injection, blastocyst culture, and either fresh or vitrified-warmed SETs were conducted. Putative confounders were investigated, and the data were adjusted through regression analyses. The primary outcome was the live birth rate (LBR) per SET according to donors' and/or recipients' BMI. The main secondary outcome was the miscarriage rate (<22 gestational weeks) per clinical pregnancy. The LBR per blastocyst SET showed no significant association with donors' BMI. Regarding recipients' BMI, instead, the multivariate odds ratio was significant in obese vs. normal-weight recipients (0.58, 95% confidence interval, 0.37–0.91). The miscarriage rate per clinical pregnancy was also significantly associated with recipients' obesity, with a multivariate odds ratio of 2.31 (95% confidence interval, 1.18–4.51) vs. normal-weight patients. A generalized additive model method was used to represent the relationship between predicted LBR or miscarriage rates and donors' or recipients' BMI; it pictured a scenario where the former outcome moderately but continuously decreases with increasing recipients' BMI to then sharply decline in the BMI range of 25–35 kg/m2. The miscarriage rate, instead, increases almost linearly with respect to both donors' and recipients' increasing BMI. Obesity mostly affects the uterus, especially because of higher miscarriage rates. Yet, poorer outcomes can be appreciated already with a BMI of 25 kg/m2 in both oocyte donors and recipients. Finer markers of nutritional homeostasis are therefore desirable; recipients should be counseled about poorer expected outcomes in cases of overweight and obesity; and oocyte banks should avoid assigning oocytes from overweight donors to overweight and obese recipients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
爱读多读完成签到,获得积分10
1秒前
2秒前
搜集达人应助dylaner采纳,获得10
4秒前
害羞大白菜完成签到,获得积分10
4秒前
汉堡包应助无糖乐采纳,获得10
4秒前
jojojojojo发布了新的文献求助10
5秒前
Hello应助喜悦傀斗采纳,获得10
5秒前
5秒前
娴娴发布了新的文献求助10
5秒前
msp发布了新的文献求助10
5秒前
wyy完成签到,获得积分20
5秒前
玛卡巴卡发布了新的文献求助10
6秒前
6秒前
6秒前
王明月发布了新的文献求助10
9秒前
仙布着急完成签到 ,获得积分10
9秒前
加油女王关注了科研通微信公众号
9秒前
Ruby完成签到,获得积分20
9秒前
在水一方应助能干的吐司采纳,获得10
9秒前
Steven发布了新的文献求助10
11秒前
追寻依风应助msp采纳,获得10
12秒前
12秒前
活力的之槐完成签到,获得积分10
12秒前
麻瓜小韩完成签到,获得积分20
13秒前
Qiao完成签到,获得积分10
13秒前
mkmimii发布了新的文献求助10
15秒前
chenfeng2163发布了新的文献求助10
16秒前
burn发布了新的文献求助10
16秒前
16秒前
量子星尘发布了新的文献求助10
18秒前
18秒前
19秒前
科研鸟完成签到,获得积分10
19秒前
整齐凝竹完成签到 ,获得积分10
22秒前
ruaruaburua发布了新的文献求助10
22秒前
田様应助科研通管家采纳,获得10
22秒前
Cc完成签到,获得积分10
22秒前
情怀应助科研通管家采纳,获得10
22秒前
Rondab应助科研通管家采纳,获得10
22秒前
Rondab应助科研通管家采纳,获得10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976177
求助须知:如何正确求助?哪些是违规求助? 3520366
关于积分的说明 11202745
捐赠科研通 3256847
什么是DOI,文献DOI怎么找? 1798509
邀请新用户注册赠送积分活动 877704
科研通“疑难数据库(出版商)”最低求助积分说明 806516