Recently, great progress has been made in nanozyme research due to the rapid development of nanomaterials and nanotechnology. MXene-based nanomaterials have gained considerable attention owing to their unique physicochemical properties. They have been found to have high enzyme-like properties, such as peroxidase, oxidase, catalase, and superoxide dismutase. In this mini-review, we present an overview of the recent progress in MXene-based nanozymes, with emphasis on their synthetic methods, hybridization, bio-catalytic properties, and biomedical applications. The future challenges and prospects of MXene-based nanozymes are also proposed.