Indole Aggregation-induced Emission Molecule Based Nanoparticles for Ablation of Mouse Cancer Cells in Vitro

Photodynamic therapy (PDT) holds the merits of high spatiotemporal precision and minimal invasiveness, emerging as a novel therapy. Herein, two aggregation-induced emission photosensitizers (AIE PSs) named TPA-YD and DPA-YD were synthesized for overcoming the dilemma of aggregation-caused fluorescence quenching (ACQ) of conventional photosensitizers. In comparison with DPA-YD, the addition of the benzene ring in TPA-YD enhanced the D-A strength, improved the AIE effect and reactive oxygen species (ROS) generation efficiency. The prepared TPA-YD nanoparticles (TPA-NPs) are promising candidates for PDT. Two indole based aggregation-induced emission (AIE) molecules are designed and synthesized. Nanoparticles based on these AIE molecules was fabricated through nanoprecipitation using 1,2-distearoylsn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) as an encapsulation materials. In comparison with DPA-YD, the TPA-YD molecule show enhanced AIE effect and reactive oxygen species (ROS) generation efficiency for mouse cancer cells ablation application.