Impacts of cardiometabolic risk factors and alcohol consumption on all-cause mortality among MASLD and its subgroups

医学 危险系数 比例危险模型 糖尿病 内科学 死亡率 代谢综合征 死亡风险 风险因素 饮酒量 2型糖尿病 人口学 肥胖 置信区间 内分泌学 社会学 化学 生物化学
作者
Mengqi Li,Wenya Chen,You Deng,Wen Xie
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier BV]
卷期号:34 (9): 2085-2094 被引量:5
标识
DOI:10.1016/j.numecd.2024.05.018
摘要

Background and aims Recently, metabolic dysfunction-associated steatotic liver disease (MASLD) has been introduced. However, research on this new nomenclature and definition remains limited. This study aims to assess the impact of cardiometabolic risk factors and alcohol consumption on all-cause mortality in MASLD and its subgroups. Methods and results We included 2408 participants with MASLD in NHANES III and their linked mortality through 2019. MASLD patients were divided into two groups based on alcohol consumption: Pure MASLD and MetALD. The Cox proportional hazard model was used to assess the association between factors and all-cause mortality. During the median 26.0-year follow-up, there were 1040 deaths. The multivariable Cox regression analysis revealed a significant increase of over two-fold in the all-cause mortality rate among patients with four or more cardiometabolic risk factors compared to those with only one. When focusing on each component of cardiometabolic risk factors individually, only diabetes and hypertension were significantly associated with all-cause mortality (p <0.05). In a subgroup analysis, each additional cardiometabolic factor was linked to an increase in all-cause mortality in both pure MASLD (hazard ratio 1.16; 95% CI 1.06-1.28; p = 0.002) and MetALD (HR 1.77; 95% CI 1.26-2.49; p = 0.001). Notably, an elevation in alcohol consumption was significantly associated with an increase in all-cause mortality rate only in the MetALD (p <0.001). Conclusions This study found that the presence of diabetes or hypertension was significantly associated with all-cause mortality. We also explored the different impacts of these factors and alcohol consumption within MASLD subgroups.
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