Cysteine substitutants emerge in lung cancer proteomes during arginine restriction

In this issue of Molecular Cell, Yang et al. 1 Yang C. Pataskar A. Feng X. Navarro J.M. Paniagua I. Jacobs J.J.L. Zaal E.A. Berkers C.C.R. Bleijerveld O.B. Agami R. Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine to cysteine substitutants. Molecular Cell. 2024; 84https://doi.org/10.1016/j.molcel.2024.04.012 Abstract Full Text Full Text PDF Google Scholar find that arginine-to-cysteine substitutants are enriched in a subset of lung cancer proteomes, potentiated by arginine deprivation, and promote resistance to chemotherapy. In this issue of Molecular Cell, Yang et al. 1 Yang C. Pataskar A. Feng X. Navarro J.M. Paniagua I. Jacobs J.J.L. Zaal E.A. Berkers C.C.R. Bleijerveld O.B. Agami R. Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine to cysteine substitutants. Molecular Cell. 2024; 84https://doi.org/10.1016/j.molcel.2024.04.012 Abstract Full Text Full Text PDF Google Scholar find that arginine-to-cysteine substitutants are enriched in a subset of lung cancer proteomes, potentiated by arginine deprivation, and promote resistance to chemotherapy. Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutantsYang et al.Molecular CellMay 16, 2024In BriefYang, Pataskar, et al. investigated the impact of arginine shortage on aberrant mRNA translation in cancer. They report the enrichment of arginine-to-cysteine substitutants in human lung cancer, link it to a tRNA misalignment mechanism, and connect it to KEAP1 pathway mutations and platinum resistance. Full-Text PDF Open Access