介孔有机硅
纳米技术
材料科学
介孔材料
化学
介孔二氧化硅
催化作用
有机化学
作者
Qian Shen,Mengda Cao,Changmin Yu,Jian Tang,Lebin Song,Yanan Ding,Linjie Ju,Ji‐Fu Wei,Lin Li,Wei Huang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-06-22
卷期号:18 (26): 16934-16946
被引量:1
标识
DOI:10.1021/acsnano.4c03069
摘要
Allergic diseases are immune system dysfunctions mediated by mast cell (MC) activation stimulated by specific allergens. However, current small molecular MC stabilizers for allergic disease prevention often require multiple doses over a long period of time and are associated with serious side effects. Herein, we develop a diselenide-bridged mesoporous silica nanostabilizer, proving that it could specifically target sensitized MCs via the recognition of IgE aptamer and IgE. Meantime, the IgE aptamer can also mitigate allergic reactions by preventing re-exposure of allergens from the surface of sensitized MCs. Furthermore, the diselenide-bridged scaffold can be reduced by the intracellular excessive ROS, subsequently achieving redox homeostasis via ROS depletion. Finally, the precise release of small molecular MC stabilizers along with the biodegradation of nanocarrier can stabilize the membranes of MCs.
科研通智能强力驱动
Strongly Powered by AbleSci AI