Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

左乙拉西坦药代动力学医学肥胖性情儿科人口年龄组药理学癫痫内科学人口学心理学精神科环境卫生社会心理学社会学

作者

Patricia D. Maglalang,Jaydeep Sinha,Kanecia O. Zimmerman,Sean McCann,Andrea N. Edginton,Christoph P. Hornik,Chi D. Hornik,William J. Muller,Amira Al‐Uzri,Marisa Meyer,Jia‐Yuh Chen,Ravinder Anand,Eliana M. Perrin,Daniel González,Daniel K. Benjamin,Phyllis Kennel,Cheryl Alderman,Zoë Sund,Kylie Opel,Rose Beci,Chi D. Hornik,Gregory L. Kearns,Matthew M. Laughon,Ian M. Paul,Janice E. Sullivan,Kelly C. Wade,Ian M. Paul,Leanne L. West,Susan M. Abdel‐Rahman,Elizabeth Payne,Lily Chen,Gina Simone,Kathleen L. O’Connor,J Cermák,Lawrence Taylor,Ramany John,William J. Muller,Ram Yogev,Laura Fearn,Sasidharan Taravath,Tiffony Blanks,Arielle Lapid,Chi D. Hornik,Melissa Harward,Kira Clark,Sarah Craven,Kimberly Grzesek,Charuta Joshi,Austin Drake,Lauri Filar,Jennifer Sargent,Arpita Lakhotia,Michael Oldham,Jens Gunter Burmester,Stephany Eubanks,Terri Simeon,Yael Shiloh‐Malawsky,Christopher L. Anderson,M. King Jolly,Shubham Joshi,Norbert Odero,Jennifer Taylor,Susan Arnold,Caryn R. Harper,Erica N. Howard,María Soledad Castaño Martínez,David Myer,Angela Walker,Martha Blackford,Michael Reed,Amanda Hodge,Tasha Capozzi,Heather Anthony,Glenn Stryjewski,Kimberly Klipner,Karen Kowal,Benjamin Traisman,Carol Nielsen,Pam Sroka,Matitiahu Berkovitch,Elkana Kohn,Catherine Litalien,Julie Autmizguine,Diane Desmarasis,Christine Massicotte,Mariana Dumitrascu,Vincent Lague,Neil A. Goldenberg,Peter M. Mourani,J. Deschenes,Domninic DiDomenico,M C Dix,Gentle Halstenson,Kathryn Malone,Kimberly Ralston,Alleluiah Rutebemberwa,Yamila Sierra,Matthew Steinbeiss,Kevin A Van,Hugh J. McMillan,Roger Zemek,Thierry Lacaze,Daniela Pohl,Angie Tuttle,Barbara Murchison,Sara Ieradi,Stuart L. Goldstein,Geoff Bradley,Stuart L. Goldstein,Theresa Mottes,Tara Terrell,Patricia Arnold,Bradley DePaoli,Bradley Gerhardt,Cassie Kirby,Kevin M. Watt,Grace Jefferson,Nicole Baisden,Heidi Tiedge,Christie Milleson,Steve Wrenn,Alicia Báez,Scott C. Denne,Brenda B. Poindexter,Gregory Sokol,Bahar Kost,Ashley Moore,Jaime Deville,Kavita Shankar,E. H. Lang,Yaron Finkelstein,Maggie Rumantir,Mobeen H. Rathore,Kathleen A. Thoma,Aércio Sebastião Borges,Philip Toltzis,David Speicher,Eloise Lemon,Brenna Vitou,Eileen Goldblatt,Ramon Adams,Catherine Tasi,Lisa Petersen,Ashlee Parsons,Laura P. James,David R. Hansberry,Michelle Hart,Howard Lee,D Pierce Ann,Janice E. Sullivan,Karrie Kernen,Susan Poff,Courtney Konow,Kelli R. McCormack Brown,Jen Comings,Andrew Michael,Jackie Perry,Michelle Wiseheart,Matthew M. Laughon,Janice Bernhardt,Ashley Mariconti,Jennifer Talbert,Michael G. Spigarelli,Catherine M.T. Sherwin,Fumiko Alger,JoAnn Narus,R M Perez,Priscilla Rosen,Yakub Salman,Kaylynn Shakespear,JYOSUKE SHIMIZU,Sanjay Dixit,Ian M. Paul

出处

期刊：Clinical Pharmacokinectics [Springer Nature]
日期：2024-05-30 卷期号：63 (6): 885-899

链接

nih.govdoi.org

标识

DOI：10.1007/s40262-024-01367-2

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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

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