The development of paliperidone nanocrystals for the treatment of schizophrenia

精神分裂症(面向对象编程) 重症监护医学 医学 精神科
作者
Phattalapol Lhaglham,Luksika Jiramonai,Xing‐Jie Liang,Bing Liu,Fangzhou Li
出处
期刊:Progress in Biomedical Engineering 卷期号:7 (1): 012002-012002
标识
DOI:10.1088/2516-1091/ad8fe7
摘要

Abstract Schizophrenia is a complex and chronic psychiatric disorder that significantly impacts patients’ quality of life. Ranking 12th among 310 diseases and injuries that result in disability, the number of patients suffering from schizophrenia continues to rise, emphasizing the urgent need for developing effective treatments. Despite the availability of effective antipsychotic drugs, over 80% of patients taking oral antipsychotics experience relapses, primarily caused by non-adherence as the high dosing frequency is required. In this review, we discuss about schizophrenia, its incidence, pathological causes, influencing factors, and the challenges of the current medications. Specifically, we explore nanocrystal technology and its application to paliperidone, making it one of the most successful long-acting antipsychotic drugs introduced to the market. We highlight the clinical advantages of paliperidone nanocrystals, including improved adherence, efficacy, long-term outcomes, patient satisfaction, safety, and cost-effectiveness. Additionally, we address the physicochemical factors influencing the drug’s half-life, which crucially contribute to long-acting medications. Further studies on nanocrystal-based long-acting medications are crucial for enhancing their effectiveness and reliability. The successful development of paliperidone nanocrystals holds great promise as a significant approach for drug development, with potential applications for other chronic disease management.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小马甲应助梦幻采纳,获得10
1秒前
子车茗应助六六采纳,获得30
2秒前
2秒前
2秒前
5秒前
Yu_6nd23完成签到,获得积分20
5秒前
hanshiyi完成签到,获得积分10
6秒前
yuan完成签到 ,获得积分10
6秒前
BWZ发布了新的文献求助10
7秒前
7秒前
JMrider发布了新的文献求助10
8秒前
kqkqk完成签到,获得积分10
8秒前
9秒前
9秒前
10秒前
Ericlee发布了新的文献求助10
10秒前
10秒前
小罗完成签到,获得积分10
13秒前
13秒前
热心访风完成签到,获得积分10
14秒前
yang发布了新的文献求助10
14秒前
Ava应助彪壮的青雪采纳,获得10
14秒前
呆萌语梦发布了新的文献求助10
14秒前
Rita完成签到,获得积分10
15秒前
桂花酒酿发布了新的文献求助10
15秒前
852应助文艺的匪采纳,获得10
15秒前
健康的抽屉完成签到,获得积分10
15秒前
小罗发布了新的文献求助10
15秒前
16秒前
kkjl发布了新的文献求助20
17秒前
wjx关注了科研通微信公众号
17秒前
梦幻发布了新的文献求助10
18秒前
希望天下0贩的0应助ing采纳,获得10
18秒前
初(*^▽^*)心完成签到,获得积分10
19秒前
19秒前
21秒前
21秒前
顾台关注了科研通微信公众号
21秒前
Akim应助卫文奎采纳,获得10
21秒前
1376完成签到,获得积分10
22秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247717
求助须知:如何正确求助?哪些是违规求助? 2890987
关于积分的说明 8265743
捐赠科研通 2559230
什么是DOI,文献DOI怎么找? 1388048
科研通“疑难数据库(出版商)”最低求助积分说明 650670
邀请新用户注册赠送积分活动 627571