Clinical Outcomes of Ileostomy Closure during versus after Adjuvant Chemotherapy in Patients with Rectal Cancer

医学 回肠造口术 结直肠癌 外科 化疗 造口(药) 狭窄 吻合 佐剂 癌症 内科学
作者
Fan He,Fuyu Yang,Chenglin Tang,Defei Chen,Dongqin Zhao,Junjie Xiong,Yu Zou,Guoquan Huang,Kun Qian
出处
期刊:Canadian Journal of Gastroenterology & Hepatology [Pulsus Group]
卷期号:2024: 1-11
标识
DOI:10.1155/2024/2410643
摘要

Background. Protective ileostomy can effectively prevent severe anastomotic leakage after rectal cancer surgery; however, the optimal timing for ileostomy closure during adjuvant chemotherapy remains unclear. This study aimed to explore the safety and long-term outcomes of early ileostomy closure during adjuvant chemotherapy. Method. Patients who underwent laparoscopic rectal cancer surgery combined with protective ileostomy and adjuvant chemotherapy between April 2017 and April 2021 were retrospectively evaluated. Patients were divided into an early closure group during chemotherapy (group A) and a late closure group after chemotherapy (group B). Results. A total of 215 patients were included in this study, with 115 in group A and 100 in group B. There were no significant differences in demographic and clinical characteristics between the two groups. In group A, durations of stoma status ( p<0.001 ) and low anterior resection syndrome (LARS) ( p<0.001 ) were shorter, and rectal stenosis ( p=0.036 ) and stoma-related complications ( p=0.007 ), especially stoma stenosis ( p=0.041 ), were less common. However, compliance with chemotherapy was worse ( p=0.009 ). There were no significant differences in operative time, postoperative hospital stay, postoperative complications, incidence and severity of LARS, disease-free survival, or overall survival between groups. Conclusion. Early ileostomy closure can effectively reduce the duration of stoma status, duration of LARS, rectal stenosis, and stoma-related complications while not affecting surgical complications and oncological outcomes. Ileostomy closure should not be delayed because of adjuvant chemotherapy. However, follow-up should be strengthened to increase compliance and integrity with chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
蔫蔫发布了新的文献求助10
1秒前
1秒前
rush发布了新的文献求助10
2秒前
zp12345发布了新的文献求助10
2秒前
lay发布了新的文献求助20
2秒前
香蕉觅云应助monkey采纳,获得10
2秒前
faiting完成签到,获得积分10
3秒前
3秒前
zej发布了新的文献求助10
3秒前
chenqingyu发布了新的文献求助10
4秒前
4秒前
曼曼完成签到,获得积分10
4秒前
weiwei完成签到 ,获得积分10
5秒前
淡淡的新之完成签到,获得积分10
5秒前
6秒前
6秒前
unite 小丘完成签到,获得积分10
6秒前
6秒前
百招完成签到,获得积分10
7秒前
喜宝完成签到 ,获得积分10
7秒前
7秒前
jim_hacker发布了新的文献求助10
7秒前
time完成签到,获得积分10
7秒前
小二郎应助细腻海蓝采纳,获得10
7秒前
YJ完成签到,获得积分10
7秒前
ldy完成签到,获得积分10
8秒前
微微完成签到,获得积分10
8秒前
瞬间默念完成签到,获得积分10
8秒前
虚心沂发布了新的文献求助10
8秒前
专一的新之完成签到 ,获得积分10
10秒前
10秒前
猫好好发布了新的文献求助10
10秒前
ghost发布了新的文献求助10
11秒前
yuhui完成签到,获得积分10
11秒前
飞云发布了新的文献求助10
12秒前
shuofeng完成签到 ,获得积分10
12秒前
高贵宛海完成签到,获得积分10
12秒前
12秒前
13秒前
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968771
求助须知:如何正确求助?哪些是违规求助? 3513729
关于积分的说明 11169450
捐赠科研通 3249084
什么是DOI,文献DOI怎么找? 1794592
邀请新用户注册赠送积分活动 875258
科研通“疑难数据库(出版商)”最低求助积分说明 804740