General Semi‐Solid Freeze Casting for Uniform Large‐Scale Isotropic Porous Scaffolds: An Application for Extensive Oral Mucosal Reconstruction

材料科学 纳米技术 多孔性 脚手架 组织工程 生物医学工程 复合材料 医学
作者
Jinlin Chen,Tianyu Zhang,Dan Liu,Fan Yang,Yuan Feng,Ao Wang,Yanchao Wang,Xueling He,Feng Luo,Jiehua Li,Hong Tan,Lu Jiang
出处
期刊:Small methods [Wiley]
卷期号:8 (7) 被引量:1
标识
DOI:10.1002/smtd.202301518
摘要

Abstract Ice‐templated porous biomaterials possess transformative potential in regenerative medicine; yet, scaling up ice‐templating processes for broader applications—owing to inconsistent pore formation—remains challenging. This study reports an innovative semi‐solid freeze‐casting technique that draws inspiration from semi‐solid metal processing (SSMP) combined with ice cream‐production routines. This versatile approach allows for the large‐scale assembly of various materials, from polymers to inorganic particles, into isotropic 3D scaffolds featuring uniformly equiaxed pores throughout the centimeter scale. Through (cryo‐)electron microscopy, X‐ray tomography, and finite element modeling, the structural evolution of ice grains/pores is elucidated, demonstrating how the method increases the initial ice nucleus density by pre‐fabricating a semi‐frozen slurry, which facilitates a transition from columnar to equiaxed grain structures. For a practical demonstration, as‐prepared scaffolds are integrated into a bilayer tissue patch using biodegradable waterborne polyurethane (WPU) for large‐scale oral mucosal reconstruction in minipigs. Systematic analyses, including histology and RNA sequencing, prove that the patch modulates the healing process toward near‐scarless mucosal remodeling via innate and adaptive immunomodulation and activation of pro‐healing genes converging on matrix synthesis and epithelialization. This study not only advances the field of ice‐templating fabrication but sets a promising precedent for scaffold‐based large‐scale tissue regeneration.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tlh完成签到 ,获得积分10
刚刚
陈彦滨完成签到 ,获得积分10
刚刚
1秒前
3秒前
3秒前
css完成签到,获得积分10
3秒前
Liufgui应助Re采纳,获得20
3秒前
Nugget完成签到,获得积分10
3秒前
yar应助潇湘雪月采纳,获得10
4秒前
宇宇发布了新的文献求助10
4秒前
shufessm完成签到,获得积分0
6秒前
6秒前
10秒前
幸福大白发布了新的文献求助30
10秒前
11秒前
肿瘤柳叶刀完成签到,获得积分10
12秒前
13秒前
13秒前
xxddw发布了新的文献求助10
14秒前
16秒前
GS11完成签到,获得积分10
17秒前
邓紫依完成签到,获得积分10
18秒前
cdytjt发布了新的文献求助60
18秒前
ai zs发布了新的文献求助10
18秒前
搜集达人应助zyw采纳,获得10
19秒前
20秒前
攀攀完成签到,获得积分10
21秒前
21秒前
Aprilapple发布了新的文献求助10
22秒前
张雯思发布了新的文献求助10
22秒前
23秒前
越野蟹关注了科研通微信公众号
24秒前
空军完成签到 ,获得积分10
26秒前
26秒前
酷波er应助moji采纳,获得10
26秒前
28秒前
传奇3应助打我呀采纳,获得30
29秒前
29秒前
Aprilapple发布了新的文献求助10
32秒前
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174