Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury

Acute lung injury (ALI) is a critical respiratory disorder with a high mortality rate and is caused by several factors. Addressing oxidative stress and inflammation is a pivotal strategy for ALI treatment. In this study, we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI. This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution. The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2 (TRPM2)-NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, offering a highly effective therapeutic approach to ALI. Our findings reveal the underlying mechanisms of this innovative nanodelivery system, showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.