Evaluation of Ketoclomazone and its Analogues as Inhibitors of 1-Deoxy-D-Xylulose 5-Phosphate Synthases and Other Thiamine Diphosphate (ThDP)-dependent Enzymes

Most pathogenic bacteria, apicomplexan parasites and plants rely on the methylerythritol phosphate (MEP) pathway to obtain precursors of isoprenoids. 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS), a thiamine diphosphate (ThDP)-dependent enzyme, catalyses the...