清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Satellite Glial Cells in Human Disease

纤维肌痛 疾病 医学 类风湿性关节炎 伤害 慢性疼痛 感觉系统 神经科学 关节炎 神经病理性疼痛 免疫学 生物 病理 内科学 受体
作者
Menachem Hanani
出处
期刊:Cells [Multidisciplinary Digital Publishing Institute]
卷期号:13 (7): 566-566 被引量:2
标识
DOI:10.3390/cells13070566
摘要

Satellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suffering from common painful diseases, such as rheumatoid arthritis and fibromyalgia, may contribute to the pain phenotype. It was found that immunoglobulins G (IgG) from fibromyalgia patients can induce pain-like behavior in mice. Moreover, these IgGs bind preferentially to SGCs and activate them, which can sensitize the sensory neurons, causing nociception. In other human diseases, the evidence is not as direct as in fibromyalgia, but it has been found that an antibody from a patient with rheumatoid arthritis binds to mouse SGCs, which leads to the release of pronociceptive factors from them. Herpes zoster is another painful disease, and it appears that the zoster virus resides in SGCs, which acquire an abnormal morphology and may participate in the infection and pain generation. More work needs to be undertaken on SGCs in humans, and this review points to several promising avenues for better understanding disease mechanisms and developing effective pain therapies.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Singularity完成签到,获得积分0
刚刚
AAA电池批发顾总完成签到,获得积分10
3秒前
刚子完成签到 ,获得积分10
10秒前
奋斗的桐完成签到 ,获得积分10
13秒前
椒盐皮皮虾完成签到 ,获得积分10
15秒前
科研通AI2S应助科研通管家采纳,获得10
29秒前
爱静静应助科研通管家采纳,获得10
29秒前
爱静静应助科研通管家采纳,获得10
29秒前
爱静静应助科研通管家采纳,获得10
30秒前
爱静静应助科研通管家采纳,获得10
30秒前
bkagyin应助科研通管家采纳,获得10
30秒前
爱静静应助科研通管家采纳,获得10
30秒前
爱静静应助科研通管家采纳,获得10
30秒前
widesky777完成签到 ,获得积分10
35秒前
路过完成签到 ,获得积分10
40秒前
番茄小超人2号完成签到 ,获得积分10
56秒前
1分钟前
HOPKINSON发布了新的文献求助10
1分钟前
wyh295352318完成签到 ,获得积分10
1分钟前
HOPKINSON完成签到,获得积分20
1分钟前
小灰灰完成签到 ,获得积分10
1分钟前
爱学习的婷完成签到 ,获得积分10
1分钟前
陈月婷完成签到 ,获得积分10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
imi完成签到 ,获得积分0
2分钟前
mm完成签到,获得积分10
2分钟前
kuyi完成签到 ,获得积分10
3分钟前
Guo完成签到 ,获得积分10
3分钟前
mengli完成签到 ,获得积分10
4分钟前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
The First Nuclear Era: The Life and Times of a Technological Fixer 500
岡本唐貴自伝的回想画集 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
Ciprofol versus propofol for adult sedation in gastrointestinal endoscopic procedures: a systematic review and meta-analysis 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3671300
求助须知:如何正确求助?哪些是违规求助? 3228149
关于积分的说明 9778643
捐赠科研通 2938406
什么是DOI,文献DOI怎么找? 1610009
邀请新用户注册赠送积分活动 760503
科研通“疑难数据库(出版商)”最低求助积分说明 736003