表观遗传学
生物
间脑
表观遗传学
基因
遗传学
基因表达
DNA甲基化
内分泌学
中枢神经系统
作者
Yaping Guo,Mingyang Hu,Hao Peng,Yan Zhang,Renzhuo Kuang,Zheyu Han,Daoyuan Wang,Yinlong Liao,Ruixian Ma,Zhuo Xu,Jiahao Sun,Yu Shen,Changzhi Zhao,Hong Ma,Di Liu,Shuhong Zhao,Yunxia Zhao
标识
DOI:10.1016/j.jgg.2024.06.017
摘要
Cold stress in low-temperature environments can trigger changes in gene expression, but epigenomics regulation of temperature stability in vital tissues, including the fat and diencephalon, is still unclear. Here, we explore the cold-induced changes in epigenomic features in the diencephalon and fat tissues of two cold-resistant Chinese pig breeds, Min and Enshi black (ES) pigs, utilizing H3K27ac CUT&Tag, RNA-seq, and selective signature analysis. Our results show significant alterations in H3K27ac modifications in the diencephalon of Min pigs and the fat of ES pigs after cold exposure. Dramatic changes in H3K27ac modifications in the diencephalon of Min pig are primarily associated with genes involved in energy metabolism and hormone regulation, whereas those in the fat of ES pig are primarily associated with immunity-related genes. Moreover, transcription factors PRDM1 and HSF1, which show evidence of selection, are enriched in genomic regions presenting cold-responsive alterations in H3K27ac modification in the Min pig diencephalon and ES pig fat, respectively. Our results indicate the diversity of epigenomic response mechanisms to cold exposure between Min and ES pigs, providing unique epigenetic resources for studies of low-temperature adaptation in large mammals.
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