益生元
益生菌
肠道微生物群
背景(考古学)
微生物群
肠道菌群
失调
临床试验
生物
医学
计算生物学
生物信息学
食品科学
免疫学
遗传学
细菌
古生物学
作者
Kevin Whelan,Margaret Alexander,Claire Gaïani,Genelle Lunken,Andrew Holmes,Heidi M. Staudacher,Stephan Theis,Maria L. Marco
出处
期刊:Nature microbiology
日期:2024-10-30
卷期号:9 (11): 2785-2794
标识
DOI:10.1038/s41564-024-01831-6
摘要
Diet is a major determinant of the gastrointestinal microbiome composition and function, yet our understanding of how it impacts the efficacy of prebiotics and probiotics is limited. Here we examine current evidence of dietary influence on prebiotic and probiotic efficacy in human studies, including potential mechanisms. We propose that habitual diet be included as a variable in prebiotic and probiotic intervention studies. This recommendation is based on the potential mechanisms via which diet can affect study outcomes, either directly or through the gut microbiome. We consider the challenges and opportunities of dietary assessment in this context. Lastly, we provide recommendations for the design, conduct and reporting of human clinical trials of prebiotics and probiotics (and other biotic interventions) to account for any effect of diet and nutrition. Here the authors make recommendations for the design of clinical trials for prebiotics and probiotics that includes consideration of diet and the gut microbiome.
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