光热治疗
氧化还原
化学
平衡
生物物理学
细胞生物学
纳米技术
生物
材料科学
无机化学
作者
Zhen Liu,Junhong Ling,Nan Wang,Xiao–kun Ouyang
标识
DOI:10.1016/j.jcis.2024.08.234
摘要
The combination of chemodynamic therapy (CDT) with photothermal therapy (PTT) is a promising approach to enhance antitumor efficacy of chemotherapeutics. In this paper, we developed novel copper-chelated polydopamine (PDA) nanoparticles (NPs) functionalized with hyaluronic acid (HA) (Cu-PDA-HA NPs) to induce apoptosis and cuproptosis-induced cell death, synergistically combining PTT and CDT. Experimental results revealed that Cu-PDA-HA NPs can respond to excessive glutathione (GSH) and hydrogen peroxide (H
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