低钾血症
医学
原发性醛固酮增多症
横纹肌溶解症
醛固酮
腺瘤
醛固酮增多症
肾上腺腺瘤
内科学
内分泌学
作者
Nobumasa Ohara,Takashi Tani,Kenshi Terajima,Tetsutaro Ozawa,Yuichiro Yoneoka,Hiroki Shimada,Yasuhiro Nakamura,Go Hasegawa,Tsutomu Nishiyama
标识
DOI:10.2169/internalmedicine.3629-24
摘要
Many cases of primary aldosteronism (PA) in patients who developed hypokalemia-induced rhabdomyolysis and underwent adrenalectomy for aldosterone-producing adenoma (APA) have been reported; however, the immunohistopathological and molecular features remain unknown. We herein report the case of a 28-year-old woman with PA who presented with hypokalemia-induced rhabdomyolysis and underwent adrenalectomy for unilateral APA. An immunohistochemical analysis revealed that most adenoma cells were positive for steroidogenic enzymes, including CYP11B2. A genetic analysis revealed a somatic mutation in the KCNJ5. These findings suggest a strong aldosterone production capacity in our patient's adenoma, which was presumably related to her severe hyperaldosteronism and the resultant hypokalemia-induced rhabdomyolysis.
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