封锁
免疫检查点
肿瘤微环境
材料科学
免疫疗法
癌症研究
自愈水凝胶
癌症免疫疗法
癌症治疗
细胞生物学
免疫系统
纳米技术
医学
免疫学
化学
癌症
受体
内科学
生物
生物化学
肿瘤细胞
高分子化学
作者
Linying Wu,Wenmin Pi,Xuemei Huang,Luping Yang,Xiang Zhang,Jihui Lu,Shuchang Yao,Xiaoyu Lin,Xian Wen Tan,Zhixia Wang,Penglong Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2024-07-31
卷期号:312: 122723-122723
标识
DOI:10.1016/j.biomaterials.2024.122723
摘要
The challenges generated by insufficient T cell activation and infiltration have constrained the application of immunotherapy. Making matters worse, the complex tumor microenvironment (TME), resistance to apoptosis collectively poses obstacles for cancer treatment. The carrier-free small molecular self-assembly strategy is a current research hotspot to overcome these challenges. This strategy can transform multiple functional agents into sustain-released hydrogel without the addition of any excipients. Herein, a coordination and hydrogen bond mediated tricomponent hydrogel (Cel hydrogel) composed of glycyrrhizic acid (GA), copper ions (Cu
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